ArticleCellular and molecular life sciences : CMLS2022
Fine-tuning of epithelial taste bud organoid to promote functional recapitulation of taste reactivity.
Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Converging Signaling Networks Drive Taste Bud Morphogenesis, Turnover, and Regeneration.International journal of molecular sciences · 2026Review
- A Taste Bud Organoid-Based Biosensor with a 3-Dimensional Microelectrode Array for Evaluating Caffeine's Impacts on Taste Sensing.BME frontiers · 2026Article
- Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Tripotent Lgr5 stem cells in the posterior tongue generate lingual, taste, and salivary gland lineages.Nature communications · 2025Article
- Pig Taste Cell-derived Organoids Synthesize Insulin.Endocrinology · 2025Article
- Organoid models for chemosensing cell studies.American journal of physiology. Cell physiology · 2025Review
- Organoid in dentistry: Models for oral biology and disease.Journal of dental sciences · 2025Review
- BuZhong YiQi Formula Alleviates Taste Disorders in Rats with Type 2 Diabetes Mellitus by Increasing the Number of Taste Buds and the Expression of Signaling Molecules in Taste Transduction Pathways.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Biomedical applications of organoids derived from the digestive system.Frontiers in cell and developmental biology · 2025Review
- Organoids in the oral and maxillofacial region: present and future.International journal of oral science · 2024Review
- Revolutionising oral organoids with artificial intelligence.Biomaterials translational · 2024Review
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- Engineered organoids in oral and maxillofacial regeneration.iScience · 2023Review
- Stem cells for organoids.Smart medicine · 2022Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Taste stem/progenitor cells from posterior mouse tongues have been used to generate taste bud organoids. However, the inaccessible location of taste receptor cells is observed in conventional organoids. In this study, we established a suspension-culture method to fine-tune taste bud organoids by apicobasal polarity alteration to form the accessible localization of taste receptor cells. Compared to conventional Matrigel-embedded organoids, suspension-cultured organoids showed comparable differentiation and renewal rates to those of taste buds in vivo and exhibited functional taste receptor cells and cycling progenitor cells. Accessible taste receptor cells enabled the direct application of calcium imaging to evaluate the taste response. Moreover, suspension-cultured organoids can be genetically altered. Suspension-cultured taste bud organoids harmoniously integrated with the recipient lingual epithelium, maintaining the taste receptor cells and gustatory innervation capacity. We propose that suspension-cultured organoids may provide an efficient model for taste research, including taste bud development, regeneration, and transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.