ReviewClinical oral investigations2022
P4 Medicine as a model for precision periodontal care.
Review in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The impact of periodontitis on physical fitness: a systematic review.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2026Pooled it
- Do all individuals benefit equally from non-surgical periodontal therapy? Secondary analyses of systematic review data.Journal of periodontal research · 2025Pooled it
- GLP-1 Receptor Agonists in Periodontology: Mechanisms, Clinical Evidence, and Implications for Care.Biomolecules · 2026Review
- Salivary Microvesicle Methylome and Microbiome Profiles in Periodontitis: An Exploratory Study.Journal of clinical periodontology · 2026Article
- Longitudinal biomarker profiles during experimental gingivitis: a predictor of susceptibility.Clinical oral investigations · 2026Article
- Exploring the Feasibility of P7 Medicine Principles in Dental Practice (P7 Dentistry).Journal of dentistry (Shiraz, Iran) · 2026Article
- Dose-dependent association of systemic comorbidities with periodontitis severity: A large population cross-sectional study.Journal of periodontology · 2026Observational
- Host-pathogen interactions in periodontitis: an integrative interkingdom perspective.Frontiers in immunology · 2026Review
- Machine learning-assisted prediction of clinical responses to periodontal treatment.Journal of periodontology · 2025Article
- The Precision Paradigm in Periodontology: A Multilevel Framework for Tailored Diagnosis, Treatment, and Prevention.Journal of personalized medicine · 2025Review
- Signature of oral microbial dysbiosis in different periodontitis risk levels.Applied microbiology and biotechnology · 2025Article
- Twelve-Month Follow-Up After the Treatment of Periodontal Conditions Using Scaling and Root Planning Alone vs. Laser-Assisted New Attachment Procedure.Diagnostics (Basel, Switzerland) · 2025Article
- The role of genome-wide DNA methylation and polymorphisms in periodontitis etiology: A narrative review.Biomolecules & biomedicine · 2025Review
- Computational approaches to investigate the relationship between periodontitis and cardiovascular diseases for precision medicine.Human genomics · 2024Review
- Strategies for the prevention of periodontal disease and its impact on general health: Latin America and the Caribbean Consensus 2024.Brazilian oral research · 2024Review
- Article
- Advances and Opportunities of Mobile Health in the Postpandemic Era: Smartphonization of Wearable Devices and Wearable Deviceization of Smartphones.JMIR mHealth and uHealth · 2024Article
- Integrating P4 Medicine in Teledentistry and M-Health in Oral, Dental, and Periodontal Care.Journal of personalized medicine · 2023Article
- Personalized Oral and Dental Care.Journal of personalized medicine · 2023Article
- A leap of faith: building the trust in human biobanks.Frontiers in genetics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesP4 Medicine is based on a proactive approach for clinical patient care incorporating the four "pillars" of prediction, prevention, personalization, and participation for patient management. The purpose of this review is to demonstrate how the concepts of P4 medicine can be incorporated into the management of periodontal diseases (particularly periodontitis) termed P4 periodontics.
methodsThis is a narrative review that used current literature to explore how P4 periodontics can be aligned with the 2018 Classification of Periodontal Diseases, current periodontal treatment paradigms, and periodontal regenerative technologies.
resultsThe proposed model of P4 periodontics is highly aligned with the 2018 Classification of Periodontal Diseases and represents a logical extension of this classification into treatment paradigms. Each stage of periodontitis can be related to a holistic approach to clinical management. The role of "big data" in future P4 periodontics is discussed and the concepts of a treat-to-target focus for treatment outcomes are proposed as part of personalized periodontics. Personalized regenerative and rejuvenative periodontal therapies will refocus our thinking from risk management to regenerative solutions to manage the effects of disease and aging.
conclusionsP4 Periodontics allows us to focus not only on early prevention and intervention but also allow for personalized late-stage reversal of the disease trajectory and the use of personalized regenerative procedures to reconstruct damaged tissues and restore them to health. CLINICAL SIGNIFICANCE: P4 Periodontics is a novel means of viewing a holistic, integrative, and proactive approach to periodontal treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.