SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2022
The use of tranexamic acid reduces blood loss in osteotomy at knee level: a systematic review.
Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The Optimal Dose, Efficacy and Safety of Tranexamic Acid on Hemorrhage Control for High Tibial Osteotomy: A Network Meta-Analysis.Orthopaedic surgery · 2025Pooled it
- The role of tranexamic acid and cryotherapy on acute postoperative pain and blood loss: a randomized controlled study following total knee arthroplasty.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Trial
- Medial open-wedge high tibial osteotomy demonstrates an 85.9% non-conversion rate and 76.8% patient satisfaction at a minimum follow-up of 10 years.Journal of experimental orthopaedics · 2026Article
- Medial Open-Wedge High Tibial Osteotomy for Double Varus Deformity and an Increased Tibial Slope.Arthroscopy techniques · 2025Article
- [Modified medial wedge osteotomy for correction of double varus deformity and increased tibial slope].Operative Orthopadie und Traumatologie · 2025Review
- Biplanar Lateral Hemi-Wedge Osteotomy for the Correction of Severe Tibial Varus Deformity.Arthroscopy techniques · 2024Article
- [Medial closing wedge osteotomy for correction of valgus deformity].Operative Orthopadie und Traumatologie · 2024Article
- [Modified pendulum osteotomy to correct severe tibial varus deformity].Operative Orthopadie und Traumatologie · 2024Article
- Postoperative management following osteotomies around the knee: a narrative review.EFORT open reviews · 2024Review
- [Subtuberosity anterior closing wedge osteotomy to correct the increased posterior slope of the tibial plateau].Operative Orthopadie und Traumatologie · 2024Review
- [Osteotomies around the knee-part 1].Operative Orthopadie und Traumatologie · 2024Article
- Double level osteotomy for medial osteoarthritis and bifocal varus malalignment has excellent short-term results while maintaining physiologic radiographic joint parameters.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Observational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAim of this systematic review was to evaluate the literature regarding the effect of tranexamic acid (TXA) on the outcome after knee osteotomy.
methodsA systematic literature search was carried out in various databases on studies on the use of tranexamic acid in osteotomies around the knee. Primary outcome criterion was the hemoglobin (drop). Secondary outcome criteria were total blood loss, drainage volume, adverse effects such as thromboembolic events, blood transfusions, wound complications and clinical scores. A meta-analysis was performed for quantitative measures. The present study was registered prospectively ( www.crd.york.ac.uk/PROSPERO ; no.: CRD42021229624).
resultsSeven studies with 584 patients (TXA group: 282 patients, non TXA group: 302 patients) Hemoglobin decrease (1.54 g/dl vs. 2.28 g/dl), blood loss (394.49 ml vs. 595.54 ml) and drainage volume (266.5 ml vs. 359.05 ml) were significantly less in the TXA group compared to the non TXA group. No thromboembolic event was noted in any study. In the non TXA group four blood transfusions were given. Eleven wound complications occurred in the non TXA group in comparison to two wound complications in the TXA group.
conclusionsThe results of the present study show that the application of TXA reduces hemoglobin drop, blood loss and drainage volume. These effects could be responsible for the lesser rate of side effects after administration of TXA during knee osteotomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.