Trial reportThe Angle orthodontist2022
Effect of low-level laser therapy on the time needed for leveling and alignment of mandibular anterior crowding.
Trial report in The Angle orthodontist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06526871 (Evaluation of Treatment Outcome of Lower Incisors Crowding Using Clear Aligners With Laser Acceleration), which is not on this map. Cited by 12 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Treatment Outcome of Lower Incisors Crowding Using Clear Aligners With Laser Acceleration (Randomized Control Study) .
Who cites it
12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- The effect of pharmacological and non-pharmacological interventions on pain control after orthodontic treatment: a systematic review and network meta-analysis.BMC oral health · 2026Pooled it
- Research Hotspots and Emerging Trends of Orthodontic-Related Discomfort and Pain: A Bibliometric Review.Pain research & management · 2025Pooled it
- The effect of physical interventions on pain control after orthodontic treatment: A systematic review and network meta-analysis.PloS one · 2024Pooled it
- Non-surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment.The Cochrane database of systematic reviews · 2023Pooled it
- The socket-shield technique in orthodontics: a method for alveolar ridge preservation.Oral and maxillofacial surgery · 2026Trial
- Effect of low-level laser therapy on en masse retraction in females with bimaxillary dentoalveolar protrusion : A single-center randomized clinical trial.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025Trial
- Effect of low-intensity pulsed ultrasound on the duration of mandibular anterior crowding correction and pain perception in adults undergoing orthodontic treatment: a single-blinded randomized control trial.Dental press journal of orthodontics · 2025Trial
- The Effectiveness of Physical Adjunctive Interventions in the Acceleration of Orthodontic Tooth Movement: An Umbrella Review and Meta-Analysis.International journal of dentistry · 2026Review
- Evaluation of the Effect of Low-level Laser Therapy on Leveling Mandibular Anterior Crowding.Turkish journal of orthodontics · 2025Article
- Effectiveness of Surgical and Non-Surgical Techniques for Accelerating Orthodontic Tooth Movement in Fixed Appliances and Aligners: A Systematic Review.Turkish journal of orthodontics · 2025Article
- Influence of orthodontic archwire (nickel-titanium versus copper-nickel-titanium) on pain in adult patients in the aligning phase of treatment with self-ligating brackets (two months of follow-up): a prospective observational pilot study.Head & face medicine · 2025Observational
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the effect of low-level laser therapy (LLLT) on overall leveling and alignment time of mandibular anterior crowding and associated pain after initial archwire placement. MATERIALS AND
methodsThirty-two females (18-25 years) with mandibular anterior crowding were randomly allocated into laser and control groups. Eligibility criteria included Angle Class I molar relationship and Little's irregularity index (LII) from 4 to 10 mm. Randomization was accomplished with a computer-generated random list. A 0.014-inch copper-nickel-titanium (Cu-NiTi) wire was inserted immediately after bonding of 0.022-inch Roth brackets followed by 0.016-inch Cu-NiTi, 0.016 × 0.022-inch NiTi then 0.017 × 0.025-inch stainless steel wire after completion of alignment. In-Ga-As laser was applied to the mandibular anterior segment in the laser group on days 3, 7, and 14, then at 1 month followed by every 2 weeks until completion of leveling and alignment. Visual analogue scale questionnaires were completed by each patient over 7 days from initial archwire placement. Digital models were used to monitor changes in the irregularity index. Blinding was applicable for outcome assessors only.
resultsThe mean time for leveling and alignment was significantly lower in the laser compared to the control group (68.2 ± 28.7 and 109.5 ± 34.7 days, respectively). The laser group displayed a significantly higher mean alignment improvement percentage as well as lower pain scores compared to the control group.
conclusionsWithin the constraints of the current study, LLLT has a potential for acceleration of anterior segment alignment as well as reduction of the pain associated with placement of initial archwires.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.