Evidence map›Paper›PMID 35343799›Full record

ArticlemSystems2022

Strain-Level Variation and Diverse Host Bacterial Responses in Episymbiotic Saccharibacteria.

Jie Nie, Daniel R Utter, Kristopher A Kerns, Eleanor I Lamont, Erik L Hendrickson, Jett Liu, Tingxi Wu, Xuesong He, Jeffrey McLean, Batbileg Bor

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

  1. A host-encoded prophage targets a Candidate Phyla Radiation bacterium and shapes episymbiotic interactions.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Oral Actinobacteria sense and defend against parasitic epibionts.bioRxiv : the preprint server for biology · 2026
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  3. Review
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  6. Identifying essential genes inJournal of bacteriology · 2025
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  7. The type IV secretion system ofMicrobial genomics · 2025
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  12. Beyond genomics in Patescibacteria: A trove of unexplored biology packed into ultrasmall bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  18. Culture-based approaches to studying "microbial dark matter".Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Article
  20. Draft Genome Sequences of Nine "Microbiology resource announcements · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jie Nie *Department of Cariology and Endodontology, Peking University School of Stomatology, Beijing, China.
Daniel R Utter *Department of Organismic and Evolutionary Biology, Harvard Universitygrid.38142.3c, Cambridge, Massachusetts, USA.
Kristopher A KernsDepartment of Periodontics, University of Washingtongrid.34477.33, Seattle, Washington, USA.
Eleanor I LamontDepartment of Periodontics, University of Washingtongrid.34477.33, Seattle, Washington, USA.
Erik L HendricksonDepartment of Periodontics, University of Washingtongrid.34477.33, Seattle, Washington, USA.
Jett LiuThe Forsyth Institute, Cambridge, Massachusetts, USA.
Tingxi WuThe Forsyth Institute, Cambridge, Massachusetts, USA.
Xuesong HeThe Forsyth Institute, Cambridge, Massachusetts, USA.
Jeffrey McLeanDepartment of Periodontics, University of Washingtongrid.34477.33, Seattle, Washington, USA.
Batbileg BorThe Forsyth Institute, Cambridge, Massachusetts, USA.
University of Washington · USHarvard University · USPeking University · CN

Funding

Domestication and characterization of TM7-the most elusive oral phylumR01DE023810 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xuesong He, Jeffrey Scott McLean · 2014 to 2026
$6.6M
Making a quantum leap in plaque research with modern sciencesR01DE020102 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HE, XUESONG, MCLEAN, JEFFREY SCOTT · 2010 to 2020
$3.7M
Impact of Saccharibacteria and their bacterial hosts in Periodontal and Inflammatory DiseasesR01DE031274 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Batbileg Bor · 2022 to 2026
$2.5M
Studying the Protective Effects of Normal Oral FloraR01DE026186 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HE, XUESONG, MCLEAN, JEFFREY SCOTT · 2016 to 2020
$2.1M
Molecular and pathogenic study of an oral TM7 strain, the first cultivated ultra-small bacteriumR00DE027719 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI BOR, BATBILEG · 2020 to 2022
$747k
Molecular and pathogenic study of an oral TM7 strain, the first cultivated ultra-small bacteriumK99DE027719 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI BOR, BATBILEG · 2018 to 2019
$268k
NIDCR NIH HHS K99 DE027719NIDCR NIH HHS R00 DE027719NIDCR NIH HHS R01 DE020102NIDCR NIH HHS R01 DE023810NIDCR NIH HHS R01 DE026186NIDCR NIH HHS R01 DE031274
6 · The paper itself

Abstract

Saccharibacteria (TM7), which are obligate episymbionts growing on the surface of host bacteria, may play an important role in oral disease, such as periodontitis (1, 2). As TM7 is a newly cultured lineage of bacteria, its research is limited by the small number of isolated representatives relative to the number of TM7 genomes assembled from culture-independent studies (3-5). A comprehensive view of both TM7 taxa and TM7 strain-level variations remains opaque. In this study, we expanded our previously developed TM7 baiting method into using many host bacteria in parallel, which allowed us to obtain 37 TM7 strains from the human oral cavity. These strains were further classified into low-enrichment (LE,

Indexed as

MicrobiotaPeriodontitisAnimalsBacteriaHumansMammalsPhylogenybacteriacandidate phyla radiationculture techniquegenomicshumanmicrobiotamouthparasiteSaccharibacteriaTM7

Identifiers

PMID35343799
PMCPMC9040727
OpenAlexW4220748946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.