Evidence map›Paper›PMID 35343760›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2022

Molecular Virology of SARS-CoV-2 and Related Coronaviruses.

Yu-An Kung, Kuo-Ming Lee, Huan-Jung Chiang, Sheng-Yu Huang, Chung-Jung Wu, Shin-Ru Shih

Abstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu-An Kung *Research Center for Emerging Viral Infections, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.
Kuo-Ming Lee *Research Center for Emerging Viral Infections, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.ORCID 0000-0002-3215-8342
Huan-Jung Chiang *Research Center for Emerging Viral Infections, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.
Sheng-Yu HuangResearch Center for Emerging Viral Infections, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.
Chung-Jung WuResearch Center for Emerging Viral Infections, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.
Shin-Ru ShihResearch Center for Emerging Viral Infections, College of Medicine, Chang Gung Universitygrid.145695.a, Taoyuan, Taiwan.ORCID 0000-0003-4874-401X

Funding

University of Washington Arboviral Research Network (UWARN)U01AI151698 · NIAID · UNIVERSITY OF WASHINGTON · PI Michael Gale, PETER MACGARR RABINOWITZ · 2020 to 2026
$13.3M
NIAID NIH HHS U01 AI151698
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The global COVID-19 pandemic continues to threaten the lives of hundreds of millions of people, with a severe negative impact on the global economy. Although several COVID-19 vaccines are currently being administered, none of them is 100% effective. Moreover, SARS-CoV-2 variants remain an important worldwide public health issue. Hence, the accelerated development of efficacious antiviral agents is urgently needed. Coronavirus depends on various host cell factors for replication. An ongoing research objective is the identification of host factors that could be exploited as targets for drugs and compounds effective against SARS-CoV-2. In the present review, we discuss the molecular mechanisms of SARS-CoV-2 and related coronaviruses, focusing on the host factors or pathways involved in SARS-CoV-2 replication that have been identified by genome-wide CRISPR screening.

Indexed as

COVID-19SARS-CoV-2Antiviral AgentsCOVID-19 VaccinesHumansPandemicsAntiviral AgentsCOVID-19 VaccinescoronavirusSARS-CoV-2

Identifiers

PMID35343760
PMCPMC9199417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.