Evidence map›Paper›PMID 35343376›Full record

ArticleAutophagy2022

The role of FYCO1-dependent autophagy in lens fiber cell differentiation.

Shahid Y Khan, Muhammad Ali, Firoz Kabir, Chan Hyun Na, Michael Delannoy, Yinghong Ma, Caihong Qiu, M Joseph Costello, J Fielding Hejtmancik, S Amer Riazuddin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Exploiting autophagy and related pathways: pioneering new horizons in cataract therapy.Apoptosis : an international journal on programmed cell death · 2025
    Review
  5. The link of FOXO1 and FOXO4 transcription factors to development of the lens.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  6. Article
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  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Shahid Y KhanThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Muhammad AliThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Firoz KabirThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Chan Hyun NaDepartment of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael DelannoyDepartment of Cell Biology and Imaging Facility, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yinghong MaYale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.
Caihong QiuYale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.
M Joseph CostelloDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, USA.
J Fielding HejtmancikOphthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
S Amer RiazuddinThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USNational Institutes of Health · USUniversity of North Carolina at Chapel Hill · USYale Cancer Center · USYale University · US

Funding

Clinical/molecular Studies In Families With Congenital Or Hereditary CataractsZIAEY000281 · NEI · NATIONAL EYE INSTITUTE · PI HEJTMANCIK, JAMES F. · 2009 to 2025
$18.1M
Identification of Lens Function Through Analysis of Human CataractsR01EY022714 · NEI · JOHNS HOPKINS UNIVERSITY · PI RIAZUDDIN, AMER · 2014 to 2018
$2.0M
NEI NIH HHS R01 EY022714
6 · The paper itself

Abstract

FYCO1 (FYVE and coiled-coil domain containing 1) is an adaptor protein, expressed ubiquitously and required for microtubule-dependent, plus-end-directed transport of macroautophagic/autophagic vesicles. We have previously shown that loss-of-function mutations in

Indexed as

CataractLens, CrystallineAnimalsAutophagyCell DifferentiationEndoplasmic ReticulumHumansMiceMicrotubule-Associated ProteinsTranscription FactorsFYCO1 protein, humanFYCO1 protein, mouseMicrotubule-Associated ProteinsTranscription FactorsAutophagycataractslens fiber cellsorganelle-free zoneorganelle removal

Identifiers

PMID35343376
PMCPMC9397473
OpenAlexW4221015757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.