Evidence map›Paper›PMID 35343375›Full record

ArticleAutophagy2022

Acute systemic knockdown of

Laura Mainz, Mohamed A F E Sarhan, Sabine Roth, Ursula Sauer, Charis Kalogirou, Markus Eckstein, Elena Gerhard-Hartmann, Helen-Desiree Seibert, Hans-Ulrich Voelker, Carol Geppert and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Selective autophagy in kidney health and disease.Nature reviews. Nephrology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Laura MainzInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Mohamed A F E SarhanInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Sabine RothInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Ursula SauerInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Charis KalogirouDepartment of Urology and Pediatric Urology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Markus EcksteinInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Elena Gerhard-HartmannInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Helen-Desiree SeibertInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Hans-Ulrich VoelkerDepartment of Pathology, Leopoldina Medizinisches Versorgungszentrum, Schweinfurt, Germany.ORCID 0000-0003-0610-2254
Carol GeppertInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Andreas RosenwaldInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Martin EilersBiocenter, Department of Biochemistry and Molecular Biology, Julius-Maximilians-University of Würzburg, Germany.
Almut SchulzeDivision of Metabolism and Microenvironment, Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Germany.ORCID 0000-0002-8199-6422
Markus DiefenbacherBiocenter, Department of Biochemistry and Molecular Biology, Julius-Maximilians-University of Würzburg, Germany.
Mathias T RosenfeldtInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.ORCID 0000-0001-7650-8458
University of Würzburg · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGerman Cancer Research Center · DELeopoldina Krankenhaus Schweinfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The notion that macroautophagy/autophagy is a potentially attractive therapeutic target for a variety of diseases, including cancer, largely stems from pre-clinical mouse studies. Most of these examine the effects of irreversible and organ confined autophagy deletion using site specific

Indexed as

AutophagyAutophagy-Related Protein 7Fatty LiverPancreasAnimalsDoxycyclineGene Knockdown TechniquesGenes, LethalMiceMice, TransgenicRNA, Small InterferingAtg7 protein, mouseAutophagy-Related Protein 7DoxycyclineRNA, Small InterferingAtg5Atg7autophagyliverpancreasshRNA transgenic mice

Identifiers

PMID35343375
PMCPMC9673934
OpenAlexW4220893196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.