Evidence map›Paper›PMID 35343370›Full record

ArticleGut microbes

The gut microbiota mediates protective immunity against tuberculosis

Fang Yang, Yi Yang, Lingming Chen, Zhiyi Zhang, Linna Liu, Chunmin Zhang, Qiongdan Mai, Yiwei Chen, Zixu Chen, Tao Lin and 10 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 75 citations in OpenAlex.

  1. Review
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  6. Upper respiratory tract commensalJournal of thoracic disease · 2026
    Article
  7. Gut microbiota remodeling inZoological research · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
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  16. Article
  17. LncRNA-CFTBS enhancesVirulence · 2025
    Article
  18. Review
  19. Review
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Fang YangDepartment of Microbiology Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Sun Yat-sen University, Guangzhou China.
Yi YangDepartment of Microbiology Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Sun Yat-sen University, Guangzhou China.
Lingming ChenDepartment of Microbiology Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Sun Yat-sen University, Guangzhou China.
Zhiyi ZhangDepartment of Microbiology Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Sun Yat-sen University, Guangzhou China.
Linna LiuDepartment of Microbiology Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Sun Yat-sen University, Guangzhou China.
Chunmin ZhangDrepartment of Pediatric Intensive Care Unit, Guangzhou Women and Children's Medical Center, Picu, Guangzhou China.
Qiongdan MaiDepartment of Microbiology Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Sun Yat-sen University, Guangzhou China.
Yiwei ChenDepartment of Microbiology Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Sun Yat-sen University, Guangzhou China.
Zixu ChenDepartment of Microbiology Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Sun Yat-sen University, Guangzhou China.
Tao LinDepartment of Microbiology Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Sun Yat-sen University, Guangzhou China.
Liang ChenGuangdong Center for Tuberculosis Control, National Clinical Research Center for Tuberculosis, Guangzhou China.
Huixin GuoGuangdong Center for Tuberculosis Control, National Clinical Research Center for Tuberculosis, Guangzhou China.
Lin ZhouGuangdong Center for Tuberculosis Control, National Clinical Research Center for Tuberculosis, Guangzhou China.
Hongbo ShenClinic and Research Center of Tuberculosis, Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Institute for Advanced Study, Tongji University School of Medicine, Shanghai, China.
Xinchun ChenDepartment of Pathogen Biology, Shenzhen University School of Medicine, Shenzhen, Guangdong China.
Lei LiuInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Guangdong Key Laboratory for Emerging Infectious Diseases, Shenzhen Third People's Hospital, National Clinical Research Center for Tuberculosis, Southern University of Science and Technology, National Clinical Research Center for Tuberculosis, Shenzhen, China.
Guoliang ZhangInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Guangdong Key Laboratory for Emerging Infectious Diseases, Shenzhen Third People's Hospital, National Clinical Research Center for Tuberculosis, Southern University of Science and Technology, National Clinical Research Center for Tuberculosis, Shenzhen, China.ORCID 0000-0002-3617-5449
Hongying LiaoDe partment of Thoracic Surgery, Thoracic Cancer Center, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Lingchan ZengClinical Research Center, Department of Medical Records Management, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China.
Gucheng ZengDepartment of Microbiology Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Sun Yat-sen University, Guangzhou China.
Sun Yat-sen University · CNCenter for Tuberculosis Control of Guangdong Province · CNGuangzhou Women and Children Medical Center · CNShenzhen University · CNSouthern University of Science and Technology · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut-lung axis has been implicated as a potential therapeutic target in lung disorders. While increasing evidence suggests that gut microbiota plays a critical role in regulating host immunity and contributing to tuberculosis (TB) development and progression, the underlying mechanisms whereby gut microbiota may impact TB outcomes are not fully understood. Here, we found that broad-spectrum antibiotics treatment increased susceptibility to

Indexed as

Gastrointestinal MicrobiomeMycobacterium tuberculosisRNA, Long NoncodingTuberculosisAnimalsDysbiosisMiceRNA, Long Noncodingcommensal gut bacteriagut-lung axisTuberculosis

Identifiers

PMID35343370
PMCPMC8966992
OpenAlexW4220680545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.