Evidence map›Paper›PMID 35343275›Full record

ArticleDiabetes & vascular disease research

Plasma advanced glycation end products and soluble receptor for advanced glycation end products as indicators of sterol content in human carotid atherosclerotic plaques.

Raphael S Pinto, Guilherme S Ferreira, Gina Camillo R Silvestre, Monique de Fátima M Santana, Valéria S Nunes, Lucas Ledesma, Paula R Pinto, Sayonara Ivana S de Assis, Ubiratan F Machado, Erasmo S da Silva and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Diabetes & vascular disease research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Raphael S PintoLaboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-2633-651X
Guilherme S FerreiraLaboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Gina Camillo R SilvestreLaboratório de Anatomia e Cirurgia Vascular (LIM 02), 117265Hospital das Clinicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Monique de Fátima M SantanaLaboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Valéria S NunesLaboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Lucas Ledesma125291Universidade Nove de Julho, São Paulo, Brazil.ORCID 0000-0001-5330-1606
Paula R PintoLaboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Sayonara Ivana S de AssisLaboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Ubiratan F MachadoDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Erasmo S da SilvaLaboratório de Anatomia e Cirurgia Vascular (LIM 02), 117265Hospital das Clinicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Marisa PassarelliLaboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-9249-4698
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade Nove de Julho · BRUniversidade de São Paulo · BRUniversidade Santa Cecília · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced glycation end products (AGEs) are independently related to cardiovascular disease (CVD) and favor cholesterol and oxysterol accumulation in macrophage foam cells. Soluble RAGE (sRAGE) impairs cellular AGE signaling alleviating the deleterious effects of AGE in atherogenesis. The association between plasma AGEs and sRAGE with the content of cholesterol, markers of cholesterol synthesis and absorption, and oxysterols in atherosclerotic plaques was evaluated in subjects undergoing carotid endarterectomy.Plasma and carotid plaques were obtained from symptomatic (

Indexed as

AtherosclerosisPlaque, AtheroscleroticGlycation End Products, AdvancedHumansReceptor for Advanced Glycation End ProductsSterolsAGER protein, humanGlycation End Products, AdvancedReceptor for Advanced Glycation End ProductsSterolsAdvanced glycation end productatherosclerosiscarotid endarterectomyoxysterolssoluble RAGE

Identifiers

PMID35343275
PMCPMC8965288
OpenAlexW4220801334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.