ArticleAging cell2022
System-level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity.
Article in Aging cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Development of nanoparticles loaded with D-mannose for topical treatment to alleviate skin aging via rescuing SIRT1 from degradation.Materials today. Bio · 2026Article
- WILDkCAT: extract, retrieve, and predict enzyme turnover numbers of constraint-based metabolic models.Bioinformatics (Oxford, England) · 2026Article
- A multi-omics molecular landscape of 30 tissues in aging female rhesus macaques.Nature methods · 2025Article
- HDAC11 deficiency regulates age-related muscle decline and sarcopenia.GeroScience · 2025Article
- Integrative systems biology approaches for analyzing microbiome dysbiosis and species interactions.Briefings in bioinformatics · 2025Review
- Systems Modeling Reveals Shared Metabolic Dysregulation and Potential Treatments in ME/CFS and Long COVID.International journal of molecular sciences · 2025Article
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- Factors involved in human healthy aging: insights from longevity individuals.Frontiers of medicine · 2025Review
- Unraveling the metabolic heterogeneity and commonality in senescent cells using systems modeling.Life medicine · 2025Article
- Genome-scale models in human metabologenomics.Nature reviews. Genetics · 2025Review
- The Biomarkers in Extreme Longevity: Insights Gained from Metabolomics and Proteomics.International journal of medical sciences · 2024Review
- Single-nucleus transcriptome inventory of giant panda reveals cellular basis for fitness optimization under low metabolism.BMC biology · 2023Article
- Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation.Aging and disease · 2023Article
- Biomarkers of aging.Science China. Life sciences · 2023Review
- Metabolic Modeling Identifies a Novel Molecular Type of Glioblastoma Associated with Good Prognosis.Metabolites · 2023Article
- Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study.International journal of environmental research and public health · 2023Observational
- Article
- System-level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity.Aging cell · 2022Article
- Construction and contextualization approaches for protein-protein interaction networks.Computational and structural biotechnology journal · 2022Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although it is well known that metabolic control plays a crucial role in regulating the health span and life span of various organisms, little is known for the systems metabolic profile of centenarians, the paradigm of human healthy aging and longevity. Meanwhile, how to well characterize the system-level metabolic states in an organism of interest remains to be a major challenge in systems metabolism research. To address this challenge and better understand the metabolic mechanisms of healthy aging, we developed a method of genome-wide precision metabolic modeling (GPMM) which is able to quantitatively integrate transcriptome, proteome and kinetome data in predictive modeling of metabolic networks. Benchmarking analysis showed that GPMM successfully characterized metabolic reprogramming in the NCI-60 cancer cell lines; it dramatically improved the performance of the modeling with an R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.