Evidence map›Paper›PMID 35343038›Full record

ArticleHIV medicine2022

Tobacco smoking and binge alcohol use are associated with incident venous thromboembolism in an HIV cohort.

Brandon Luu, Stephanie Ruderman, Robin Nance, Joseph A C Delaney, Jimmy Ma, Andrew Hahn, Susan R Heckbert, Matthew J Budoff, Kristina Crothers, William C Mathews and 21 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HIV medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 11 institutions in 2 countries.

Brandon LuuNorthern Ontario School of Medicine, Thunder Bay, Ontario, Canada.ORCID 0000-0002-7203-5283
Stephanie RudermanUniversity of Washington, Seattle, Washington, USA.ORCID 0000-0002-0058-5729
Robin NanceUniversity of Washington, Seattle, Washington, USA.
Joseph A C DelaneyUniversity of Washington, Seattle, Washington, USA.
Jimmy MaUniversity of Washington, Seattle, Washington, USA.
Andrew HahnUniversity of Washington, Seattle, Washington, USA.
Susan R HeckbertUniversity of Washington, Seattle, Washington, USA.
Matthew J BudoffLundquist Institute at Harbor-UCLA, Torrance, California, USA.
Kristina CrothersUniversity of Washington, Seattle, Washington, USA.
William C MathewsUniversity of California, San Diego, California, USA.
Katerina ChristopolousUniversity of California, San Francisco, California, USA.
Peter W HuntUniversity of California, San Francisco, California, USA.
Joseph EronUniversity of North Carolina, Chapel Hill, North Carolina, USA.
Richard MooreJohns Hopkins University, Baltimore, Maryland, USA.
Jeanne KerulyJohns Hopkins University, Baltimore, Maryland, USA.
William B LoberUniversity of Washington, Seattle, Washington, USA.
Greer A BurkholderUniversity of Alabama at Birmingham, Birmingham, Alabama, USA.
Amanda WilligUniversity of Alabama at Birmingham, Birmingham, Alabama, USA.
Geetanjali ChanderJohns Hopkins University, Baltimore, Maryland, USA.
Mary E McCaulJohns Hopkins University, Baltimore, Maryland, USA.
Karen CropseyUniversity of Alabama at Birmingham, Birmingham, Alabama, USA.
Conall O'CleirighMassachusetts General Hospital, Boston, Massachusetts, USA.
Inga PeterMount Sinai Hospital, New York, New York, USA.
Matthew FeinsteinNorthwestern University, Chicago, Illinois, USA.
Judith I TsuiUniversity of Washington, Seattle, Washington, USA.
Sara LindstroemUniversity of Washington, Seattle, Washington, USA.
Michael SaagUniversity of Alabama at Birmingham, Birmingham, Alabama, USA.
Mari M KitahataUniversity of Washington, Seattle, Washington, USA.
Heidi M CraneUniversity of Washington, Seattle, Washington, USA.
Lydia N DrumrightUniversity of Washington, Seattle, Washington, USA.
Bridget M WhitneyUniversity of Washington, Seattle, Washington, USA.
University of Washington · USJohns Hopkins University · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USMassachusetts General Hospital · USMount Sinai Hospital · USNorthwestern University · USNOSM University · CAUCLA Medical Center · USUniversity of California San Diego · USUniversity of North Carolina at Chapel Hill · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
UNC MACS/WIHS Combined Cohort Study Clinical Research SiteU01HL146194 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michael Bradley Drummond, Michelle Floris-Moore · 2019 to 2026
$23.2M
Johns Hopkins HIV Clinical CohortU01DA036935 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2014 to 2024
$14.9M
HOST DEFENSE TRAINING IN ALLERGY AND INFECTIOUS DISEASEST32AI007044 · NIAID · UNIVERSITY OF WASHINGTON · PI DAVID Neal FREDRICKS · 1985 to 2026
$14.6M
University of North Carolina Womens Interagency HIV Study UNC WIHSU01AI103390 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADIMORA, ADAORA A · 2013 to 2018
$11.0M
Alcohol Research Consortium in HIV: Relapse Prevention ArmP01AA029544 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI HUTTON, HEIDI · 2021 to 2025
$7.1M
3/4 Alcohol Research Consortium in HIV - Epidemiological Research Arm (ARCH-ERA)U01AA020793 · NIAAA · UNIVERSITY OF WASHINGTON · PI CRANE, HEIDI M., LAU, BRYAN · 2011 to 2020
$5.8M
Substance use patterns and contexts: impact on epigenetic age and prevention strategies in an HIV clinical care cohortR01DA047045 · NIDA · UNIVERSITY OF WASHINGTON · PI Heidi M. Crane, Joseph Austin Delaney · 2018 to 2026
$5.1M
NHLBI NIH HHS R01 HL126538NHLBI NIH HHS R01 HL156792NHLBI NIH HHS U01 HL146194NIAAA NIH HHS K24 AA027483NIAAA NIH HHS P01 AA029544NIAAA NIH HHS U01 AA020793NIAAA NIH HHS U01 AA020802NIAAA NIH HHS U24 AA020801NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI094189NIAID NIH HHS R24 AI067039NIAID NIH HHS T32 AI007044NIAID NIH HHS U01 AI103390NIA NIH HHS R33 AG067069NIDA NIH HHS K24 DA062568NIDA NIH HHS R01 DA044112NIDA NIH HHS R01 DA047045NIDA NIH HHS U01 DA036935
6 · The paper itself

Abstract

backgroundPeople with HIV (PWH) are at increased risk of cardiovascular comorbidities and substance use is a potential predisposing factor. We evaluated associations of tobacco smoking and alcohol use with venous thromboembolism (VTE) in PWH.

methodsWe assessed incident, centrally adjudicated VTE among 12 957 PWH within the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort between January 2009 and December 2018. Using separate Cox proportional hazards models, we evaluated associations of time-updated alcohol and cigarette use with VTE, adjusting for demographic and clinical characteristics. Smoking was evaluated as pack-years and never, former, or current use with current cigarettes per day. Alcohol use was parameterized using categorical and continuous alcohol use score, frequency of use, and binge frequency.

resultsDuring a median of 3.6 years of follow-up, 213 PWH developed a VTE. One-third of PWH reported binge drinking and 40% reported currently smoking. In adjusted analyses, risk of VTE was increased among both current (HR: 1.44, 95% CI: 1.02-2.03) and former (HR: 1.44, 95% CI: 0.99-2.07) smokers compared to PWH who never smoked. Additionally, total pack-years among ever-smokers (HR: 1.10 per 5 pack-years; 95% CI: 1.03-1.18) was associated with incident VTE in a dose-dependent manner. Frequency of binge drinking was associated with incident VTE (HR: 1.30 per 7 days/month, 95% CI: 1.11-1.52); however, alcohol use frequency was not. Severity of alcohol use was not significantly associated with VTE.

conclusionsCurrent smoking and pack-year smoking history were dose-dependently associated with incident VTE among PWH in CNICS. Binge drinking was also associated with VTE. Interventions for smoking and binge drinking may decrease VTE risk among PWH.

Indexed as

Binge DrinkingHIV InfectionsVenous ThromboembolismEthanolHumansProportional Hazards ModelsProspective StudiesRisk FactorsTobacco SmokingEthanolbinge drinkingHIVsmokingsubstance usevenous thromboembolism

Identifiers

PMID35343038
PMCPMC9515244
OpenAlexW4220654660

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.