ArticleJournal of oral rehabilitation2022
Cytokines in temporomandibular joint synovial fluid and tissue in relation to inflammation.
Article in Journal of oral rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Temporomandibular Joint Arthroscopic Lysis and Lavage Compared to Arthrocentesis in Disc Displacement Without Reduction: a Randomised, Double-blind, Controlled Trial
Temporomandibular Joint Arthroscopic Lysis and Lavage Compared to Operative Arthroscopy in Disc Displacement With Reduction: a Randomised, Double-blind, Controlled Trial
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- The Role of Proinflammatory Cytokines in Temporomandibular Disorders: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- The Role of Biomarkers in Temporomandibular Disorders: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Intra-Articular Monoclonal Antibodies in Temporomandibular Joint Disorders: Current Evidence.Cells · 2026Review
- Precision Medicine in Temporomandibular Joint Disorders: A Synovial Fluid Biomarker-Based Literature Review.Medicina (Kaunas, Lithuania) · 2026Review
- Multimodal deep learning with anatomically constrained attention for screening MRI-detectable TMJ abnormalities from panoramic images.NPJ digital medicine · 2026Article
- Presence of bacterial DNA in synovial fluid from the temporomandibular joint in patients with temporomandibular joint disorders.Frontiers in oral health · 2026Article
- Psychological stress and gut microbiota regulation of osteoarthritis progression: mechanisms and therapeutic strategies.Frontiers in microbiology · 2026Review
- Association between TMD signs and symptoms, condyle alterations and joint effusion: an MRI retrospective study.Brazilian oral research · 2026Observational
- Article
- Stabilization Splint Therapy for Patients with Temporomandibular Disorders Improves Opening Movements and Jaw Limitation and Attenuates Pain by Influencing the Levels of IL-7, IL-8, and IL-13 in the Gingival Crevicular Fluid.Medicina (Kaunas, Lithuania) · 2025Article
- Association between circulating inflammatory proteins and temporomandibular disorders: insight from a two-sample Mendelian randomization analysis.Journal of applied oral science : revista FOB · 2025Article
- Energy metabolism dysfunction and therapeutic strategies for treating temporomandibular disorders.Frontiers in medicine · 2025Review
- Intra-Articular Physiological Saline in Temporomandibular Disorders May Be a Treatment, Not a Placebo: A Hypothesis, Systematic Review, and Meta-Analysis.Journal of clinical medicine · 2024Article
- Effects of Hyaluronic Acid (HA) and Platelet-Rich Plasma (PRP) on Mandibular Mobility in Temporomandibular Joint Disorders: A Controlled Clinical Trial.Biomolecules · 2024Article
- Genetic Influences of Proinflammatory Cytokines on Pain Severity in Patients with Temporomandibular Disorders.International journal of molecular sciences · 2024Article
- General joint hypermobility in temporomandibular joint disease; clinical characteristics, biomarkers, and surgical aspects.Heliyon · 2023Article
- Association of HMGB1 levels in synovial fluid with the severity of temporomandibular joint osteoarthritis.BMC musculoskeletal disorders · 2023Article
- IL-37 counteracts inflammatory injury in the temporomandibular joint via the intracellular pathway.Frontiers in pharmacology · 2023Article
- Cytokines in temporomandibular joint synovial fluid and tissue in relation to inflammation.Journal of oral rehabilitation · 2022Article
- Biomarkers in orofacial pain conditions: A narrative review.Journal of oral biology and craniofacial researchReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSynovial tissue is known to be the origin of inflammation in joint disease. Despite this, synovial fluid is the main biological specimen of choice in temporomandibular joint (TMJ) inflammation and pathology biomarker research. No comparison of TMJ protein content between synovial fluid and synovial tissue has been made.
objectivesThe aim of this study was to investigate whether cytokine concentrations in synovial fluid can be related to cytokine concentrations in synovial tissue and to analyse correlation of clinical parameters reflecting local inflammation to cytokine concentrations.
methodsSynovial tissue and fluid samples were obtained during the same surgical procedure from a cohort of 101 patients with TMJ disorders. Interleukin (IL) 1β, IL-6, IL-8, IL-10 and tumour necrosis factor α (TNF-α) were analysed in the samples and an intraindividual correlation made. Various patient-specific factors related to TMJ inflammation were associated with the cytokine concentrations in synovial fluid and tissue.
resultsNo correlation between cytokine concentration in synovial fluid and synovial tissue was found, except for IL-8 (ρ = .284, p = .024). Synovial tissue cytokines correlated strongly to inflammation-related factors: diagnosis (IL-1β, p = .001; TNF-α, p = .000; IL-10, p = .000), TMJ palpation pain (IL-1β, p = .024; TNF-α, p = .025), synovitis score (IL-1β, p = .015) and subjective TMJ pain (TNF-α, p = .016). Synovial fluid cytokines showed no significant relations to inflammation.
conclusionsThe investigated cytokine concentrations showed weak correlations between synovial fluid and synovial tissue, besides IL-8. Synovial tissue appeared to reflect inflammation to a higher extent than synovial fluid. Thus, suggesting that synovial tissue research should complement synovial fluid in future explorations of TMJ pathology and inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.