Evidence map›Paper›PMID 35342779›Full record

ArticleCurrent opinion in behavioral sciences2022

Temperamental risk for anxiety: emerging work on the infant brain and later neurocognitive development.

Courtney A Filippi, Emilio A Valadez, Nathan A Fox, Daniel S Pine

Open access · hybridAbstract read
In one paragraph

Article in Current opinion in behavioral sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Longitudinal Changes in Infant Attention-Related Brain Networks and Fearful Temperament.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Article
  2. Article
  3. Article
  4. Neurodevelopmental Pathways from Temperamental Fear to Anxiety.Current topics in behavioral neurosciences · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Annual Research Review: Developmental pathways linking early behavioral inhibition to later anxiety.Journal of child psychology and psychiatry, and allied disciplines · 2023
    Review
  9. Attentional biases in human anxiety.Neuroscience and biobehavioral reviews · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Courtney A FilippiEmotion and Development Branch, National Institute of Mental Health, Bethesda, MD, 20892, United States.
Emilio A ValadezDepartment of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, 20742, United States.
Nathan A FoxDepartment of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, 20742, United States.
Daniel S PineEmotion and Development Branch, National Institute of Mental Health, Bethesda, MD, 20892, United States.
Indra (Spain) · ESNational Institute of Mental Health · USUniversity of Maryland, College Park · US

Funding

Fmri Studies Of Risk For Mood And Anxiety Disorders In ChildrenZIAMH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$28.3M
Trajectories of Behavioral Inibition and Risk for AnxietyU01MH093349 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI FOX, NATHAN A · 2011 to 2020
$6.6M
Neural Origins of Temperamental Risk for AnxietyR21MH122976 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI FOX, NATHAN A · 2021 to 2022
$425k
Intramural NIH HHS Z99 MH999999Intramural NIH HHS ZIA MH002782NIMH NIH HHS R21 MH122976NIMH NIH HHS U01 MH093349
6 · The paper itself

Abstract

Behavioral inhibition (BI), an infant temperament characterized by distress to novelty, is amongst the strongest early risk markers for future anxiety. In this review, we highlight three ways that recent research elucidates key details about the pathophysiology of anxiety in individuals with BI. First, atypical amygdala connectivity during infancy may be related to BI. Second, developmental shifts in cognitive control may portend risk for anxiety for children with BI. Lastly, distinct cognitive control processes moderate the BI-anxiety relation in different ways. Studying the intersection of these three streams of work may inform prevention or intervention work.

Identifiers

PMID35342779
PMCPMC8955382
OpenAlexW4213441348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.