Evidence map›Paper›PMID 35342760›Full record

ArticleBioMed research international2022

Development of Niacinamide/Ferulic Acid-Loaded Multiple Emulsion and Its

Sidra Huma, Haji Muhammad Shoaib Khan, Shakeel Ijaz, Muhammad Sarfraz, Hafiz Saqib Zaka, Aousaf Ahmad

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Ferulic Acid Use for Skin Applications: A Systematic Review.The Journal of clinical and aesthetic dermatology · 2025
    Review
  2. Article
  3. Article
  4. Chemical Profiling, Formulation Development,Molecules (Basel, Switzerland) · 2022
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Sidra HumaDepartment of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100 Punjab, Pakistan.
Haji Muhammad Shoaib KhanDepartment of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100 Punjab, Pakistan.ORCID https://orcid.org/0000-0002-0727-3453
Shakeel IjazDepartment of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100 Punjab, Pakistan.ORCID https://orcid.org/0000-0002-0143-7429
Muhammad SarfrazCollege of Pharmacy, Al Ain University, Al Ain, UAE.ORCID https://orcid.org/0000-0002-0516-4966
Hafiz Saqib ZakaDepartment of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100 Punjab, Pakistan.
Aousaf AhmadDepartment of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100 Punjab, Pakistan.
Islamia University of Bahawalpur · PKQuaid-i-Azam University · PKAl Ain University · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Multiple emulsions have the ability to incorporate both lipophilic and hydrophilic actives in the same preparation and facilitate permeation of active ingredients through skin. The current study was aimed at formulating niacinamide/ferulic acid-loaded stable multiple emulsion (MNF) and its Methods: Both the compounds were evaluated for their radical scavenging potential by the DPPH method and FTIR analysis. Then, placebo and active formulations were prepared using a double emulsification method and were investigated for stability testing (changes in color, odor, and liquefaction on centrifugation, pH, and globule size) for a period of three months. Afterwards, MNF was investigated for Results: Results demonstrated that MNF showed a non-Newtonian behavior rheologically and both MNF and placebo were stable at different storage conditions. Entrapment efficiency, zeta potential, and zeta size were 93.3%, -5.88 mV, and 0.173 Conclusion: It is evident that niacinamide and ferulic acid can be successfully incorporated in a stable multiple emulsion which has potent cosmeceutical effects on human skin.

Indexed as

CosmeceuticalsCoumaric AcidsEmulsionsHumansNiacinamideParticle SizeSkinCosmeceuticalsCoumaric AcidsEmulsionsferulic acidNiacinamide

Identifiers

PMID35342760
PMCPMC8947885
OpenAlexW4221075867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.