ArticleRespiratory medicine case reports2022
Rituximab rescue therapy for autoimmune pulmonary alveolar proteinosis.
Article in Respiratory medicine case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- A Case of Autoimmune Pulmonary Alveolar Proteinosis.Clinical case reports · 2026Article
- Recombinant GM-CSF drug evaluation review.Immunotherapy · 2025Review
- Summary for clinicians: ERS guidelines on pulmonary alveolar proteinosis.Breathe (Sheffield, England) · 2025Review
- A Comprehensive Outlook on Pulmonary Alveolar Proteinosis-A Review.International journal of molecular sciences · 2024Review
- Article
- Alveolar macrophages in pulmonary alveolar proteinosis: origin, function, and therapeutic strategies.Frontiers in immunology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare lung disease characterised by abnormal alveolar surfactant accumulation due to macrophage dysfunction. Whole lung lavage (WLL) is the cornerstone of first-line aPAP therapy, but effective rescue treatments have not yet been well established. We report a case of a 41-year-old man with aPAP in whom further WLL is contraindicated. His diagnosis was established using a combination of classical radiological findings, positive serum GM-CSF IgG antibodies and bronchoalveolar lavage (BAL) findings. Following a literature review of emerging therapies, a decision was made to treat with a course of rituximab to suppress GM-CSF autoantibody production and restore alveolar surfactant-macrophage homeostasis. A significant clinical response was demonstrated within 6 months with improvements in arterial oxygenation, respiratory membrane gas diffusion, six-minute walk test and radiological findings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.