Evidence map›Paper›PMID 35342659›Full record

ArticleComputational molecular bioscience2022

A Study of Differential Gene Expression and Core Canonical Pathways Involved in Rhenium Ligand Treated Epithelial Mesenchymal Transition (EMT) Induced A549 Lung Cancer Cell Lines by INGENUITY Software System.

Christopher Krauss, Chelsey Aurelus, Kayla Johnston, Joseph Hedley, Satyendra Banerjee, Sarah Wisniewski, Quentin Reaves, Khadimou Dia, Shenell Brown, Victoria Bartlet and 8 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational molecular bioscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Christopher KraussDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Chelsey AurelusDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Kayla JohnstonDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Joseph HedleyDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Satyendra BanerjeeDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Sarah WisniewskiDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Quentin ReavesDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Khadimou DiaDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Shenell BrownDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Victoria BartletDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Sheritta GavinDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Jazmine CuffeeDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Narendra BanerjeeDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Kuldeep RawatDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Santosh MandalDepartment of Chemistry, Morgan State University, Baltimore, MD, USA.
Zahidur AbedinPrimBio Research Institute LLC, Exton, PA, USA.
Somiranjan GhoshDepartment of Pediatrics and Child Health, Howard University Medical School, Washington DC, USA.
Hirendra BanerjeeDepartment of Natural Sciences and Department of Health and Human Studies, Elizabeth City State University, University of NC, Elizabeth City, NC, USA.
Elizabeth City State University · USBioscience (China) · CNHoward University · US

Funding

Elizabeth City State University Minority Access to Research Careers (E-MARC) UndeT34GM100831 · NIGMS · ELIZABETH CITY STATE UNIVERSITY · PI BANERJEE, HIRENDRA N · 2012 to 2022
$1.9M
NIGMS NIH HHS T34 GM100831
6 · The paper itself

Abstract

Rhenium compounds have shown anti-cancer properties against many different types of cancer cell lines; however, the cellular signaling mechanisms involved in the cytotoxic properties of rhenium-based compounds were never deciphered or reported. In this manuscript, we report the results of an investigation done by RNA sequencing of rhenium treated A549 lung cancer cell lines along with an untreated vehicular control, analyzed by the Ingenuity Pathway Analysis (IPA) software system to decipher the core canonical pathways involved in rhenium induced cancer cell death. A549 EMT lung cancer cell lines were treated with rhenium ligand (Tricarbonylperrhenato(bathocuproine)rhenium(I), PR7) for seven days along with vehicular control. RNA was isolated from the treated and control cells and sequenced by a commercial company (PrimBio Corporation). The RNA sequencing data was analyzed by the INGNUITY software system and the core canonical pathways involved with differential gene expression were identified. Our report is showing that there are several cellular pathways involved in inducing cell death by rhenium-based compound PR7.

Indexed as

EpithelialLung CancerRhenium Compounds

Identifiers

PMID35342659
PMCPMC8955764
OpenAlexW4214891479

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.