Evidence map›Paper›PMID 35342539›Full record

ArticleChemical science2021

Rational design of iridium-porphyrin conjugates for novel synergistic photodynamic and photothermal therapy anticancer agents.

Liping Zhang, Yun Geng, Lijuan Li, Xiaofan Tong, Shi Liu, Xingman Liu, Zhongmin Su, Zhigang Xie, Dongxia Zhu, Martin R Bryce

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. IUCrData · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Near-Infrared Afterglow ONOOACS applied materials & interfaces · 2023
    Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Liping ZhangKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University 5268 Renmin Street Changchun Jilin Province 130024 P. R. China zhudx047@nenu.edu.cn.
Yun GengKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University 5268 Renmin Street Changchun Jilin Province 130024 P. R. China zhudx047@nenu.edu.cn.ORCID https://orcid.org/0000-0002-2381-2373
Lijuan LiKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University 5268 Renmin Street Changchun Jilin Province 130024 P. R. China zhudx047@nenu.edu.cn.
Xiaofan TongKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University 5268 Renmin Street Changchun Jilin Province 130024 P. R. China zhudx047@nenu.edu.cn.
Shi LiuState Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 P. R. China xiez@ciac.ac.cn.ORCID https://orcid.org/0000-0002-1182-975X
Xingman LiuKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University 5268 Renmin Street Changchun Jilin Province 130024 P. R. China zhudx047@nenu.edu.cn.
Zhongmin SuKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University 5268 Renmin Street Changchun Jilin Province 130024 P. R. China zhudx047@nenu.edu.cn.ORCID https://orcid.org/0000-0003-0156-7191
Zhigang XieState Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 P. R. China xiez@ciac.ac.cn.ORCID https://orcid.org/0000-0003-2974-1825
Dongxia ZhuKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University 5268 Renmin Street Changchun Jilin Province 130024 P. R. China zhudx047@nenu.edu.cn.ORCID https://orcid.org/0000-0003-3002-0144
Martin R BryceDepartment of Chemistry, Durham University Durham DH1 3LE UK m.r.bryce@durham.ac.uk.ORCID https://orcid.org/0000-0003-2097-7823
Northeast Normal University · CNChinese Academy of Sciences · CNDurham University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Near-infrared (NIR) emitters are important probes for biomedical applications. Nanoparticles (NPs) incorporating mono- and tetranuclear iridium(iii) complexes attached to a porphyrin core have been synthesized. They possess deep-red absorbance, long-wavelength excitation (635 nm) and NIR emission (720 nm). TD-DFT calculations demonstrate that the iridium-porphyrin conjugates herein combine the respective advantages of small organic molecules and transition metal complexes as photosensitizers (PSs): (i) the conjugates retain the long-wavelength excitation and NIR emission of porphyrin itself; (ii) the conjugates possess highly effective intersystem crossing (ISC) to obtain a considerably more long-lived triplet photoexcited state. These photoexcited states do not have the usual radiative behavior of phosphorescent Ir(iii) complexes, and they play a very important role in promoting the singlet oxygen (

Identifiers

PMID35342539
PMCPMC8874234
OpenAlexW3151132129

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.