ArticleJournal of oncology2022
circNBPF10/miR-224 Axis Regulates PBX3 to Promote the Malignant Progression of Lung Cancer.
Article in Journal of oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- PHAX enhanced LIN28B-mediated PBX3 mRNA stability to promote esophageal cancer development.Cancer science · 2025Article
- Two microRNAs of plasma-derived small extracellular vesicles as biomarkers for metastatic non-small cell lung cancer.BMC pulmonary medicine · 2023Article
- Integrated Single-Trait and Multi-Trait GWASs Reveal the Genetic Architecture of Internal Organ Weight in Pigs.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to reveal the potential effect of circNBPF10 on the malignant progression of lung cancer. The expression levels of circNBPF10 in lung cancer tissues and cell lines were detected via real-time quantitative PCR (RT-qPCR). The relationship between circNBPF10 expression and lung cancer metastasis was further analyzed. Effects on lung cancer cells after the knockout or overexpression of circNBPF10 were detected. Subsequently, the regulatory relationship of circNBPF10 with miR-224 was detected by using the dual-luciferase reporter gene. In addition, the role of pre-B-cell homeo box 3 (PBX3) in the progression of lung cancer affected by circNBPF10 was evaluated through a rescue experiment. circNBPF10 was highly expressed in lung cancer tissues and lung cancer cell lines. The expression level of circNBPF10 was significantly higher in patients with lung cancer and lymphatic metastasis or distant metastasis than in patients with nonmetastatic lung cancer. The downregulation of circNBPF10 reduced the proliferation, migration, and invasion of lung cancer cells. In lung cancer cells, circNBPF10 negatively regulated the expression of miR-224, whereas miR-224 directly targeted the expression of PBX3. The results of the rescue experiment confirmed that PBX3 was the key gene for the promoting effect of circNBPF10 on the malignant progression of lung cancer. circNBPF10 was highly expressed in lung cancer tissues and was associated with distant metastasis and poor prognosis in patients with lung cancer. circNBPF10 upregulated PBX3 by targeting miR-224 and promoted the malignant progression of lung cancer.
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Registered trials
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