ArticleCanada communicable disease report = Releve des maladies transmissibles au Canada2022
Outcomes of infectious syphilis in pregnant patients and maternal factors associated with congenital syphilis diagnosis, Alberta, 2017-2020.
Article in Canada communicable disease report = Releve des maladies transmissibles au Canada, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Prenatal characteristics and factors contributing to congenital syphilis: A descriptive analysis of cases reported to the Canadian Paediatric Surveillance Program June 2021 through May 2023.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Healthcare Professionals' Perspectives on the Direct Referral Pathway for Syphilis Management in Western Sydney.Archives of sexual behavior · 2026Article
- Syphilis in pregnancy: A practical guide for prenatal care providers.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Evolution and Possible Explanations for the Trends in New HIV Diagnoses in Alberta, Saskatchewan, and Manitoba, Compared to the Rest of Canada, 1985-2022.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2025Article
- Congenital Syphilis in Canada: What Can We Do?Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2024Article
- Rising congenital syphilis rates in Canada, 1993-2022.Frontiers in public health · 2024Article
- The rise of congenital syphilis in Canada: threats and opportunities.Frontiers in public health · 2024Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Congenital syphilis (CS) is a significant public health challenge, requiring early diagnosis and treatment to improve infant outcomes. The aim of this study is to describe public health outcomes of infectious syphilis cases among pregnant patients and factors associated with a CS diagnosis for their infant. Methods: We conducted a retrospective review of demographic and clinical characteristics of infectious syphilis cases diagnosed during pregnancy and resulting infant outcomes in Alberta from 2017 to 2020 from the provincial communicable disease database. Adequate maternal treatment was defined as receiving at least one dose of Benzathine penicillin G-LA 2.4 million units IM at least 28 days before delivery. Univariate and multivariate analysis was performed to determine factors associated with CS diagnosis using SPSS version 25. Results: A total of 374 cases of infectious syphilis were diagnosed in pregnancy, with two patients being diagnosed twice in a single pregnancy. The majority (79.1%; n=296) of women had a live birth, followed by therapeutic abortion (9.4%; n=35), stillbirth (7.5%; n=28) and spontaneous abortion (4.0%; n=15). Infant records (n=265) were available for review (n=117 CS cases and 148 non-cases). Correlates associated with CS were screening time in third trimester (adjusted odds ratio [AOR] 8.4, 95% confidence interval [CI], 2.9-24.6) and fewer than 28 days before delivery (AOR 8.1, 1.4-47.8 [vs. first and second trimester] and inadequate treatment (AOR 86.1, CI, 15.9-466.5). Among the CS cases, 23.1% (n=27) were stillborn compared with one (0.7%) stillbirth in the non-CS infants ( Conclusion: The early identification and treatment of syphilis in pregnancy is crucial to preventing poor infant outcomes.
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