Evidence map›Paper›PMID 35342358›Full record

ArticleInternational journal of biological sciences2022

Specific overexpression of SIRT1 in mesenchymal stem cells rescues hematopoiesis niche in BMI1 knockout mice through promoting CXCL12 expression.

Jinbo Li, Xing Li, Wen Sun, Jiao Zhang, Quanquan Yan, Jun Wu, Jianliang Jin, Ruinan Lu, Dengshun Miao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. The Role of SIRT1 in Leukemia.Current treatment options in oncology · 2024
    Review
  5. Article
  6. Role of SIRT1 in Chemoresistant Leukemia.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jinbo LiDepartment of Pharmacology, Institute of Medical and Health Science, Hebei Medical University, Shijiazhuang, Hebei 050011, China.
Xing LiDepartment of Immuno-oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.
Wen SunJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Jiao ZhangState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Quanquan YanState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Jun WuDepartment of Human Anatomy, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Jianliang JinDepartment of Human Anatomy, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Ruinan LuDepartment of Hematology, Jiangsu People's Hospital, Nanjing, Jiangsu 210029, China.
Dengshun MiaoState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Nanjing Medical University · CNHebei Medical University · CNPlastic Surgery Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoblastic lineage cells (OBCs) are bone-building cells and essential component of hematopoietic niche, but mechanisms whereby bone-building and hematopoiesis-supportive activities of OBCs could be regulated simultaneously remain largely unknown. Here we found that B cell-specific Moloney murine leukemia virus integration site 1 (Bmi1) was involved in such a co-regulatory mechanism. In this study, we first found that, accompanied with marked decline of osteogenic activity, the hematopoietic niche in Bmi1 knockout (KO) mice was severely impaired and manifested as CXCL12 expression falls and LSK homing failure; however, intratibial injection with CXCL12 effectively facilitated LSK accumulation in bone marrow of Bmi1 KO mice. To try to rescue these defects in Bmi1 KO mice, we generated Bmi1

Indexed as

Mesenchymal Stem CellsSirtuin 1AnimalsChemokine CXCL12HematopoiesisMiceMice, KnockoutPolycomb Repressive Complex 1Proto-Oncogene ProteinsBmi1 protein, mouseChemokine CXCL12Cxcl12 protein, mousePolycomb Repressive Complex 1Proto-Oncogene ProteinsSirt1 protein, mouseSirtuin 1Bmi1CXCL12.hematopoietic stem cell nichemesenchymal progenitor cellsSirt1

Identifiers

PMID35342358
PMCPMC8935221
OpenAlexW4225551946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.