ArticleJournal of pediatric rehabilitation medicine2022
Spasticity-related pain in children/adolescents with cerebral palsy. Part 1: Prevalence and clinical characteristics from a pooled analysis.
Article in Journal of pediatric rehabilitation medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 8 citations in OpenAlex.
- Does botulinum neurotoxin A make walking easier in children with cerebral palsy? A randomized clinical trial.Developmental medicine and child neurology · 2025Trial
- Radial extracorporeal shock wave therapy for the management of spasticity in cerebral palsy: a randomized controlled trial with different time intervals between sessions.Frontiers in neurologyTrial
- Patterns of habitual physical activity in children and adolescents with cerebral palsy (GMFCS I-II).Frontiers in sports and active living · 2026Article
- Chronic pain, spasticity, and maternal burnout in children with spastic cerebral palsy.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Cerebral Palsy Link to Sensorimotor System, Cognition, Emotion and Nociplastic Pain.Children (Basel, Switzerland) · 2025Review
- Review
- Observational
- Clinical and maternal factors associated with pain and quality of life in children with cerebral palsy.African journal of disability · 2025Article
- Foot and lower leg pain in children and adults with cerebral palsy: a population-based register study on 5,122 individuals.BMC musculoskeletal disorders · 2024Article
- Utilizing combination intrathecal baclofen and analgesic medication to manage spasticity and pain in patients with pediatric-onset disability: Case series.Journal of pediatric rehabilitation medicine · 2024Article
- Spasticity-related pain in children/adolescents with cerebral palsy. Part 2: IncobotulinumtoxinA efficacy results from a pooled analysis.Journal of pediatric rehabilitation medicine · 2023Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA large prospective database from three Phase 3 studies allowed the study of spasticity-related pain (SRP) in pediatric cerebral palsy (CP).
methodsBaseline (pretreatment) SRP data occurring during different activities in children/adolescents (aged 2-17 years, ambulant/nonambulant) with uni-/bilateral spastic CP was obtained using the Questionnaire on Pain caused by Spasticity (QPS; six modules specific to spasticity level [lower limb (LL) or upper limb (UL)] and type of respondent [child/adolescent, interviewer, or parent/caregiver]).
resultsAt baseline, 331 children/adolescents with LL- and 155 with UL-spasticity completed at least one key item of their modules; LL/UL QPS modules of parent/caregivers were at least partially completed (key items) by 841/444 parents/caregivers. SRP with at least one activity at baseline was self-reported in 81.9% /69.7% (LLs/ULs) of children/adolescents with spasticity. Parents/caregivers observed LL/UL SRP behaviors in 85.9% /77.7% of their children, with multiple body regions affected. SRP negatively affected the great majority of the children in various ways. Child/adolescent-reported mean SRP intensity and parent/caregiver-observed mean SRP behavior frequencies were higher for LLs than ULs, and the level of SRP increased with more physically demanding activities.
conclusionThese data suggest SRP is more common and intense in pediatric CP than generally thought, emphasizing the need for effective, long-term pain management.
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