ArticleBiological psychiatry2022
Association of Amygdala Development With Different Forms of Anxiety in Autism Spectrum Disorder.
Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Value coding by primate amygdala neurons complies with the continuity axiom of economic choice theory.Journal of neurophysiology · 2026Article
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- Identifying Neurobehavioral Biomarkers of Anxiety and Treatment Response Using Virtual Reality, Electroencephalography, Magnetic Resonance Imaging, and Related Multimodal Assessments: A Longitudinal Study Protocol.Journal of clinical medicine · 2025Article
- Assessment of Brain Morphological Abnormalities and Neurodevelopmental Risk Copy Number Variants in Individuals from the UK Biobank.International journal of molecular sciences · 2025Article
- A unique neural and behavioral profile of social anxiety in autism.Research square · 2025Article
- Sensory Processing and Anxiety: Within and Beyond the Autism Spectrum.Current topics in behavioral neurosciences · 2025Review
- Translational Insights From Cell Type Variation Across Amygdala Subnuclei in Rhesus Monkeys and Humans.The American journal of psychiatry · 2024Article
- Anxiety in children and adolescents with autism spectrum disorder: behavioural phenotypes and environmental factors.BMC psychology · 2024Article
- Executive function, limbic circuit dynamics and repetitive and restricted behaviors in children with autism spectrum disorder.Frontiers in neuroscience · 2024Article
- The amygdala and the pursuit of future rewards.Frontiers in neuroscience · 2024Review
- Structural Brain Imaging Biomarkers of Autism Spectrum Disorder.Advances in neurobiology · 2024Review
- Article
- Anxiety in children and youth with autism spectrum disorder and the association with amygdala subnuclei structure.Autism : the international journal of research and practice · 2023Article
- Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Potential Diagnostic Biomarkers in Autism Spectrum Disorders: A Preliminary Study.International journal of molecular sciences · 2023Article
- Linehan's biosocial model applied to emotion dysregulation in autism: a narrative review of the literature and an illustrative case conceptualization.Frontiers in psychiatry · 2023Review
- Compassion-focused therapy with autistic adults.Frontiers in psychology · 2023Article
- Default mode and fronto-parietal network associations with IQ development across childhood in autism.Journal of neurodevelopmental disorders · 2022Article
- Altered Development of Amygdala-Connected Brain Regions in Males and Females with Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Glial receptor PLXNB2 regulates schizophrenia-related stress perceptionFrontiers in immunology · 2022Article
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Authors and funding
13 authors at 5 institutions in 3 countries.
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Abstract
backgroundThe amygdala is widely implicated in both anxiety and autism spectrum disorder. However, no studies have investigated the relationship between co-occurring anxiety and longitudinal amygdala development in autism. Here, the authors characterize amygdala development across childhood in autistic children with and without traditional DSM forms of anxiety and anxieties distinctly related to autism.
methodsLongitudinal magnetic resonance imaging scans were acquired at up to four time points for 71 autistic and 55 typically developing (TD) children (∼2.5-12 years, 411 time points). Traditional DSM anxiety and anxieties distinctly related to autism were assessed at study time 4 (∼8-12 years) using a diagnostic interview tailored to autism: the Anxiety Disorders Interview Schedule-IV with the Autism Spectrum Addendum. Mixed-effects models were used to test group differences at study time 1 (3.18 years) and time 4 (11.36 years) and developmental differences (age-by-group interactions) in right and left amygdala volume between autistic children with and without DSM or autism-distinct anxieties and TD children.
resultsAutistic children with DSM anxiety had significantly larger right amygdala volumes than TD children at both study time 1 (5.10% increase) and time 4 (6.11% increase). Autistic children with autism-distinct anxieties had significantly slower right amygdala growth than TD, autism-no anxiety, and autism-DSM anxiety groups and smaller right amygdala volumes at time 4 than the autism-no anxiety (-8.13% decrease) and autism-DSM anxiety (-12.05% decrease) groups.
conclusionsDisparate amygdala volumes and developmental trajectories between DSM and autism-distinct forms of anxiety suggest different biological underpinnings for these common, co-occurring conditions in autism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.