ArticleACS nano2022
Enzyme Purification Improves the Enzyme Loading, Self-Propulsion, and Endurance Performance of Micromotors.
Article in ACS nano, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Chemotactic Gold Nanozyme-Powered Flasklike Pentosan Nanobots for Tumor-Specific Drug Delivery.Advanced healthcare materials · 2026Article
- Chemotaxis of ATPase-Powered Nanoparticles up Extra- and Intracellular ATP Gradients.Nano letters · 2026Article
- Calcium sulphate-based soybean salting-out urease purification for enzyme-induced carbonate precipitation in road base stabilisation.Scientific reports · 2026Article
- Micro/nano motors treating of digestive system diseases.Journal of nanobiotechnology · 2025Review
- MOF Coating Enhances the Ion Tolerance of Micromotors.Angewandte Chemie (International ed. in English) · 2025Article
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- Hyaluronic Acid-Based Nanomotors: Crossing Mucosal Barriers to Tackle Antimicrobial Resistance.ACS applied materials & interfaces · 2025Article
- Review
- Urease-powered micro/nanomotors: Current progress and challenges.Journal of pharmaceutical analysis · 2025Review
- Multiorifice acoustic microrobot for boundary-free multimodal 3D swimming.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Ultrasensitive ImmunoMag-CRISPR Lateral Flow Assay for Point-of-Care Testing of Urinary Biomarkers.ACS sensors · 2024Article
- Analyte Sensing with Catalytic Micromotors.Biosensors · 2022Review
- Enzyme-powered micro- and nano-motors: key parameters for an application-oriented design.Chemical science · 2022Review
- Multistimuli-responsive microrobots: A comprehensive review.Frontiers in robotics and AI · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enzyme-powered micro- and nanomotors make use of biocatalysis to self-propel in aqueous media and hold immense promise for active and targeted drug delivery. Most (if not all) of these micro- and nanomotors described to date are fabricated using a commercially available enzyme, despite claims that some commercial preparations may not have a sufficiently high degree of purity for downstream applications. In this study, the purity of a commercial urease, an enzyme frequently used to power the motion of micro- and nanomotors, was evaluated and found to be impure. After separating the hexameric urease from the protein impurities by size-exclusion chromatography, the hexameric urease was subsequently characterized and used to functionalize hollow silica microcapsules. Micromotors loaded with purified urease were found to be 2.5 times more motile than the same micromotors loaded with unpurified urease, reaching average speeds of 5.5 μm/s. After comparing a number of parameters, such as enzyme distribution, protein loading, and motor reusability, between micromotors functionalized with purified
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Registered trials
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