ArticleJournal of oral microbiology2022
Comparative analysis of the oral microbiome of burning mouth syndrome patients.
Article in Journal of oral microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Salivary Proteome-Microbiome Profiling in Burning Mouth Syndrome Might Highlight Mucin-Related Host-Microbe Features.Journal of oral rehabilitation · 2026Article
- Burning Mouth Syndrome, the Oral Microbiome, and Lactic Acid Bacteria: A Comprehensive Review of Clinical Features, Microbial Dysbiosis, and Probiotic Therapeutic Potential.Microorganisms · 2026Review
- Clinical and gustatory features in taste disorder patients based on oral Candida culture status.Clinical oral investigations · 2026Article
- Investigating oral microbiome profiles of children with cleft lip and palate in different states of caries.Journal of oral microbiology · 2026Article
- Associations between pain, anxiety and depression and mindfulness in patients with burning mouth syndrome: a cross-sectional study.Journal of oral & facial pain and headache · 2025Article
- Role of microbiota in pain: From bench to bedside.iMetaOmics · 2025Review
- Differences in Gut Microbiota Composition Depending on the Site of Pain in Patients with Chronic Pain.Journal of pain research · 2025Article
- Distinctive salivary oral microbiome in patients with burning mouth syndrome depending on pain intensity compared to healthy subjects.Journal of dental sciences · 2025Article
- A pilot study of the relationship between salivary microbial characteristics and endocrine and immune function in patients with burning mouth syndrome.Clinical oral investigations · 2024Article
- Oral Microbiome: A Review of Its Impact on Oral and Systemic Health.Microorganisms · 2024Review
- Potential salivary and serum biomarkers for burning mouth syndrome and their relationship with anxiety/depression.Journal of dental sciences · 2024Article
- Alterations and correlations in dental plaque microbial communities and metabolome characteristics in patients with caries, periodontitis, and comorbid diseases.BMC oral health · 2024Article
- Comprehensive analysis of the oral microbiota and metabolome change in patients of burning mouth syndrome with psychiatric symptoms.Journal of oral microbiology · 2024Article
- Association of medications with burning mouth syndrome in Taiwanese aged patients.Journal of dental sciences · 2023Article
- Metataxonomic and metaproteomic profiling of the oral microbiome in oral lichen planus - a pilot study.Journal of oral microbiology · 2023Article
- Anti-Foodborne pathogens and disease · 2022Review
- Characterization of the unique oral microbiome of children with Down syndrome.Scientific reports · 2022Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burning mouth syndrome (BMS) is a chronic pain condition accompanied by unpleasant burning sensations of the oral mucosa. While multiple factors were proposed for the etiology, evidence suggested a neuropathic pain origin while others suspected the use of antibiotics as the underlying cause. Interestingly, several reports demonstrated the intimate interaction of the nervous system and the microbiome. The current study aims to elucidate the correlation of the oral microbiome with the pathophysiology of the primary BMS. Microbiome samples obtained from the unstimulated whole saliva of 19 primary BMS patients and 22 healthy controls were sequenced and analyzed of the V3-V4 region of 16S rRNA gene. There was a distinct difference in the microbial composition between the BMS and the control groups at all taxonomic levels. Alpha diversity indexes of the oral microbiome were significantly lower in the BMS group. The samples were readily distinguished by multidimensional scaling analysis and linear discriminant analysis effect size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.