Evidence map›Paper›PMID 35341020›Full record

ArticleACS bio & med chem Au2022

Evolution of Methods for the Study of Cobalamin-Dependent Radical SAM Enzymes.

Erica K Sinner, Daniel R Marous, Craig A Townsend

Open access · goldAbstract read
In one paragraph

Article in ACS bio & med chem Au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Mechanistic insight into radicalNatural product reports · 2026
    Review
  4. Review
  5. 4″-Methyl-ACS chemical biology · 2026
    Article
  6. Structural basis for iterative methylation by a cobalamin-dependent radicalProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Structural Evidence for DUF512 as a RadicalACS bio & med chem Au · 2024
    Article
  13. Article
  14. Review
  15. ThnL, a B12-dependent radicalProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Article
  17. The Atypical Cobalamin-DependentJournal of the American Chemical Society · 2022
    Article
  18. Structure of a BNature · 2022
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Erica K SinnerDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0003-2417-9319
Daniel R MarousDepartment of Chemistry, Wittenberg University, Springfield, Ohio 45504, United States.ORCID 0000-0002-8161-3057
Craig A TownsendDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Johns Hopkins University · USWittenberg University · US

Funding

Biosynthesis of Beta-Lactam AntibioticsR37AI014937 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOWNSEND, CRAIG ARTHUR · 2004 to 2013
$5.2M
Biosynthesis of Beta Lactam AntibioticsR01AI121072 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOWNSEND, CRAIG ARTHUR · 2016 to 2025
$4.9M
The Chemistry-Biology Interface Program at Johns Hopkins UniversityT32GM080189 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROKITA, STEVEN E · 2008 to 2022
$3.5M
B LACTAM AND AMINO ACID DERIVED ANTIBIOTIC BIOSYNTHESISR01AI014937 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOWNSEND, CRAIG A · 1985 to 2003
$1.5M
NIAID NIH HHS R01 AI014937NIAID NIH HHS R01 AI121072NIAID NIH HHS R37 AI014937NIGMS NIH HHS T32 GM080189
6 · The paper itself

Abstract

While bioinformatic evidence of cobalamin-dependent radical

Indexed as

B12biosynthesiscarbapenemcobalaminnatural productsradical SAM enzyme

Identifiers

PMID35341020
PMCPMC8950095
OpenAlexW3206425985

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.