Evidence map›Paper›PMID 35341019›Full record

ArticleChemistry of materials : a publication of the American Chemical Society2021

Soft Materials that Intercept, Respond to, and Sequester Bacterial Siderophores.

Benjamin J Ortiz, James Jennings, William S Gross, Thiago M A Santos, Ti-Yu Lin, Douglas B Weibel, David M Lynn

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry of materials : a publication of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Benjamin J OrtizDepartment of Chemical and Biological Engineering, 1415 Engineering Dr., University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-5016-9427
James JenningsDepartment of Chemistry, 1101 University Ave., University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-1213-4607
William S GrossDepartment of Biochemistry, 433 Babcock Dr., University of Wisconsin-Madison, Madison, WI 53706, USA.
Thiago M A SantosDepartment of Biochemistry, 433 Babcock Dr., University of Wisconsin-Madison, Madison, WI 53706, USA.
Ti-Yu LinDepartment of Biochemistry, 433 Babcock Dr., University of Wisconsin-Madison, Madison, WI 53706, USA.
Douglas B WeibelDepartment of Chemistry, 1101 University Ave., University of Wisconsin-Madison, Madison, WI 53706, USA.
David M LynnDepartment of Chemical and Biological Engineering, 1415 Engineering Dr., University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-3140-8637
University of Wisconsin–Madison · US

Funding

Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
NIGMS NIH HHS T32 GM008505
6 · The paper itself

Abstract

We report the design and characterization of Fe-containing soft materials that respond to, interface with, and/or sequester Fe-chelating 'siderophores' that bacteria use to scavenge for iron and regulate iron homeostasis. We demonstrate that metal-organic network coatings fabricated by crosslinking tannic acid with iron(III) are stable in bacterial growth media, but erode upon exposure to biologically relevant concentrations of enterobactin and deferoxamine B, two siderophores produced by Gram-negative and Gram-positive bacteria, respectively. Our results are consistent with changes in network stability triggered by the extraction of iron(III) and reveal rates of siderophore-induced disassembly to depend upon both siderophore concentration and affinity for iron(III). These coatings also disassemble when incubated in the presence of cultures of wild-type

Identifiers

PMID35341019
PMCPMC8945880
OpenAlexW3180181213

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.