Evidence map›Paper›PMID 35340896›Full record

ArticleCommunications in nonlinear science & numerical simulation2022

Modeling calcium dynamics in neurons with endoplasmic reticulum: existence, uniqueness and an implicit-explicit finite element scheme.

Qingguang Guan, Gillian Queisser

Abstract read
In one paragraph

Article in Communications in nonlinear science & numerical simulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Qingguang GuanDepartment of Mathematics, Temple University, Philadelphia, PA 19122, USA.
Gillian QueisserDepartment of Mathematics, Temple University, Philadelphia, PA 19122, USA.

Funding

CRCNS: Collaboration toward an experimentally validated multiscale model of rTMSR01MH118930 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI QUEISSER, GILLIAN · 2018 to 2020
$497k
NIMH NIH HHS R01 MH118930
6 · The paper itself

Abstract

Like many other biological processes, calcium dynamics in neurons containing an endoplasmic reticulum is governed by diffusion-reaction equations on interface-separated domains. Interface conditions are typically described by systems of ordinary differential equations that provide fluxes across the interfaces. Using the calcium model as an example of this class of ODE-flux boundary interface problems, we prove the existence, uniqueness and boundedness of the solution by applying comparison theorem, fundamental solution of the parabolic operator and a strategy used in Picard's existence theorem. Then we propose and analyze an efficient implicit-explicit finite element scheme which is implicit for the parabolic operator and explicit for the nonlinear terms. We show that the stability does not depend on the spatial mesh size. Also the optimal convergence rate in

Indexed as

68Q2568R1068U05calcium dynamicscoupled reaction diffusion equationsexistence and uniquenessimplicit-explicit FEM schemeODE controlled interfacesstability and convergence

Identifiers

PMID35340896
PMCPMC8954672

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.