ReviewFrontiers in bioengineering and biotechnology2022
Haemodynamic Wall Shear Stress, Endothelial Permeability and Atherosclerosis-A Triad of Controversy.
Review in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Vascular adaptations to blood flow restriction resistance training with different cuff types: the role of retrograde shear stress.European journal of applied physiology · 2025Trial
- Hemodynamic Metrics and Arterial Dysfunction: Insights From a Novel Microfluidic Device.International journal for numerical methods in biomedical engineering · 2026Article
- Hemadyne: accordion-inspired perfusion for microphysiological systems.Nature communications · 2026Article
- Parent Artery Disease-Related Stroke: What Is the Impact on Endovascular Treatment? A Narrative Review.Journal of clinical medicine · 2026Review
- The impact of stenting on hemodynamic environment of tortuous coronary artery: results derived from a numerical simulation model.Frontiers in bioengineering and biotechnology · 2026Article
- The Impact of Stenosis Severity on Hemodynamic Parameters in the Iliac Artery: A Fluid-Structure Interaction Study.Bioengineering (Basel, Switzerland) · 2025Article
- Distinct inflammatory pathways shape atherosclerosis in different vascular beds.European heart journal · 2025Review
- Endovascular structures of the basilar artery as forms of the basilar nonfusion spectrum.Scientific reports · 2025Article
- Temporal evolution of hemodynamics in murine arteriovenous fistula: A micro-CT based CFD study.PLoS computational biology · 2025Article
- Endothelial Stiffening Induced by CD36-Mediated Lipid Uptake Leads to Endothelial Barrier Disruption and Contributes to Atherosclerotic Lesions.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- How Does HDL Participate in Atherogenesis? Antioxidant Activity Versus Role in Reverse Cholesterol Transport.Antioxidants (Basel, Switzerland) · 2025Review
- Role of shear stress-induced red blood cell released ATP in atherosclerosis.American journal of physiology. Heart and circulatory physiology · 2025Article
- The Role of 4D Flow MRI-derived Wall Shear Stress in Aortic Disease: A Comprehensive Review.Reviews in cardiovascular medicine · 2025Review
- An in silico analysis of heart rate impact on wall shear stress hemodynamic parameters in aortic coarctation.Scientific reports · 2025Article
- The effects of carotid plaque classification and bifurcation angle on plaque: a computational fluid dynamics simulation.Frontiers in physiology · 2025Article
- Relative Residence Time Can Account for Half of the Anatomical Variation in Fatty Streak Prevalence Within the Right Coronary Artery.Annals of biomedical engineering · 2025Article
- Narrowings of the Deep Cerebral Perforating Arteries Ostia: Geometry, Structure, and Clinical Implications.Journal of stroke · 2025Article
- Personalized PDAC chip with functional endothelial barrier for tumour biomarker detection: A platform for precision medicine applications.Materials today. Bio · 2024Article
- What Can We Learn from the Scalp Hair's Trace Element Content? The Relationship with the Advancement of Coronary Artery Disease.Journal of clinical medicine · 2024Article
- Molecular Mechanisms Regulating Vascular Endothelial Permeability.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
A striking feature of atherosclerosis is its patchy distribution within the vascular system; certain arteries and certain locations within each artery are preferentially affected. Identifying the local risk factors underlying this phenomenon may lead to new therapeutic strategies. The large variation in lesion prevalence in areas of curvature and branching has motivated a search for haemodynamic triggers, particular those related to wall shear stress (WSS). The fact that lesions are rich in blood-derived lipids has motivated studies of local endothelial permeability. However, the location of lesions, the underlying haemodynamic triggers, the role of permeability, the routes by which lipids cross the endothelium, and the mechanisms by which WSS affects permeability have all been areas of controversy. This review presents evidence for and against the current consensus that lesions are triggered by low and/or oscillatory WSS and that this type of shear profile leads to elevated entry of low density lipoprotein (LDL) into the wall via widened intercellular junctions; it also evaluates more recent evidence that lesion location changes with age, that multidirectional shear stress plays a key role, that LDL dominantly crosses the endothelium by transcytosis, and that the link between flow and permeability results from hitherto unrecognised shear-sensitive mediators.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.