ReviewAdvances in orthopedics2022
The Clinical History and Basic Science Origins of Transcutaneous Osseointegration for Amputees.
Review in Advances in orthopedics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Meta-analytic evaluation of complications and longevity of bone-anchored prostheses in lower extremity amputees: does design matter?Musculoskeletal surgery · 2026Pooled it
- Analyzing research trends and developments in osseointegration in patients with extremity amputations: Systematic bibliometric analysis and research recommendations.Prosthetics and orthotics international · 2025Pooled it
- Bone-anchored prostheses for transfemoral amputation: a systematic review of outcomes, complications, patient experiences, and cost-effectiveness.Frontiers in rehabilitation sciences · 2024Pooled it
- Tibial Bone-Anchored Prostheses: A Narrative Review of the Literature and Reflection on 10 Years of Surgical Practice.Annals of biomedical engineering · 2026Review
- Enhancing skin-implant integration in lower-limb transcutaneous prostheses: From interface biology to bioactive, antimicrobial and cell-based strategies.Journal of orthopaedic translation · 2026Review
- Innovations in Implant Osseointegration: Biomaterials, Surface Engineering, and Translational Strategies.Journal of biomedical materials research. Part A · 2026Review
- Lower extremity osseointegration for amputees with diabetes mellitus and vascular disease.OTA international : the open access journal of orthopaedic trauma · 2026Article
- Lower limb osseointegrated prosthetics: are we standing on the edge of a new era?Journal of orthopaedic surgery and research · 2026Review
- Percutaneous exposure for tibia osseointegration: reduced antibiotics, improved perioperative metrics, and greater pain reduction versus open exposure.OTA international : the open access journal of orthopaedic trauma · 2025Article
- Clinical implementation of MRI for evaluation of titanium press-fit osseointegration implants.OTA international : the open access journal of orthopaedic trauma · 2025Article
- Breaking Barriers-The Promise and Challenges of Limb Osseointegration Surgery.Medicina (Kaunas, Lithuania) · 2025Article
- Lower Extremity Osseointegration Postoperative Rehabilitation Protocols: A Scoping Review.Physical therapy · 2025Article
- Transfemoral Osseointegration in Association With Total Hip Replacement: Observational Cohort Study of Patients With Follow-Up Exceeding 2 Years.Arthroplasty today · 2024Article
- Transcutaneous osseointegration for amputees.OTA international : the open access journal of orthopaedic trauma · 2024Review
- Impact of topography and added TiN-coating on adult human dermal fibroblasts after seeding on titanium surface in-vitro.Journal of biomaterials applications · 2024Article
- Development of an evidence-based diagnostic algorithm for infection in patients with transcutaneous osseointegration following amputation.Journal of bone and joint infection · 2024Article
- Bone density changes after five or more years of unilateral lower extremity osseointegration: Observational cohort study.Bone reports · 2023Article
- Osseointegration Following Transfemoral Amputation After Infected Total Knee Replacement: A Case Series of 10 Patients With a Mean Follow-up of 5 Years.Arthroplasty today · 2022Article
- Use of a "Fascial-Sock" Technique to Manage the Stump and Stoma After Insertion of an Osseointegrated Implant in Transfemoral Amputees.JB & JS open accessArticle
- Transcutaneous Osseointegration for Amputees as a Result of Sepsis Management: A Case Series of Nine Patients with a Mean Follow-up of 4 Years.Strategies in trauma and limb reconstructionReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcutaneous osseointegration for amputees (TOFA) refers to an intramedullary metal endoprosthesis which passes transcutaneously to connect with a limb exoprosthesis. The first recognizably modern experiments and attempts occurred in the 1940s. Multiple researchers using a plethora of materials and techniques over the following 50 years identified principles and obstacles which informed the first long-term successful surgery in 1990. Unfortunately, the current mainstream TOFA literature presents almost exclusively subsequent developments, generally omitting prior research, leading to some historical mistakes being repeated. Given the increasing interest and surgical volume of TOFA, this literature review was performed to delineate TOFA's basic science and surgical origins and to integrate these early efforts within the contemporary understanding. Studying this research could protect and benefit future patients, surgeons, and implant developers as TOFA is entering a phase of increased attention and innovation. The aim of this article is to provide a focused reference of foundational research, much of which is difficult to identify and retrieve, for clinicians and researchers.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.