Evidence map›Paper›PMID 35340597›Full record

ReviewBiophysical reviews2022

Peripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease.

Amy Li, K Campbell, S Lal, Y Ge, A Keogh, P S Macdonald, P Lau, John Lai, W A Linke, J Van der Velden and 4 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biophysical reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Biophysical reviews · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 4 countries.

Amy LiDepartment of Pharmacy & Biomedical Sciences, La Trobe University, Bendigo, VIC Australia.ORCID 0000-0001-5413-3771
K CampbellDepartment of Physiology, University of Kentucky, Lexington, KY USA.
S LalSydney Heart Bank, University of Sydney, Sydney, Australia.
Y GeDepartment of Cell and Regenerative Biology, Department of Chemistry, Human Proteomics Program, University of Wisconsin-Madison, Madison, WI USA.
A KeoghHeart Transplant Unit, St Vincent's Public Hospital, Victoria St, Darlinghurst 2010, Sydney, Australia.
P S MacdonaldSt Vincent's Hospital Cardiology, Darlinghurst, Australia.
P LauAustralian Genome Research Facility, Melbourne, Australia.
John LaiAustralian Genome Research Facility, Brisbane, Australia.
W A LinkeClinic for Cardiology and Pneumology, University Medical Center, Göttingen, Germany.
J Van der VeldenVU University Medical Center, Amsterdam, The Netherlands.
A FieldSt Vincent's Hospital Pathology, Darlinghurst, Australia.
B MartinacVictor Chang Cardiac Research Institute, 405 Liverpool St, Darlinghurst, Australia.
M Grosser23Strands, 107 Pirramina Rd, Pyrmont, Australia.
Cristobal Dos RemediosSydney Heart Bank, University of Sydney, Sydney, Australia.
The University of Sydney · AUAGRF Ltd · AUVictor Chang Cardiac Research Institute · AUAmsterdam UMC Location Vrije Universiteit Amsterdam · NLSt Vincent's Hospital Sydney · AUUniversitätsmedizin Göttingen · DEUniversity of Kentucky · USUniversity of Wisconsin–Madison · USUNSW Sydney · AU

Funding

Dual filament control of myocardial power and hemodynamicsR01HL148785 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Kenneth S Campbell, Thomas Kampourakis · 2020 to 2026
$3.2M
Length-dependent activation in human myocardiumR01HL149164 · NHLBI · UNIVERSITY OF KENTUCKY · PI CAMPBELL, KENNETH S, TANNER, BERTRAND C.W. · 2020 to 2023
$2.8M
NHLBI NIH HHS R01 HL148785NHLBI NIH HHS R01 HL149164
6 · The paper itself

Abstract

In this review, we present our current understanding of peripartum cardiomyopathy (PPCM) based on reports of the incidence, diagnosis and current treatment options. We summarise opinions on whether PPCM is triggered by vascular and/or hormonal causes and examine the influence of comorbidities such as preeclampsia. Two articles published in 2021 strongly support the hypothesis that PPCM may be a familial disease. Using large cohorts of PPCM patients, they summarised the available genomic DNA sequence data that are expressed in human cardiomyocytes. While PPCM is considered a disease predominately affecting the left ventricle, there are data to suggest that some cases also involve right ventricular failure. Finally, we conclude that there is sufficient evidence to warrant an RNAseq investigation and that this would be most informative if performed at the cardiomyocytes level rather than analysing genomic DNA from the peripheral circulation. Given the rarity of PPCM, the combined resources of international human heart tissue biobanks have assembled 30 ventricular tissue samples from PPCM patients, and we are actively seeking to enlarge this patient base by collaborating with human heart tissue banks and research laboratories who would like to join this endeavour.

Indexed as

Gene mutation in cardiomyocytesHeart failure in pregnancyPeripartum cardiomyopathy

Identifiers

PMID35340597
PMCPMC8921403
OpenAlexW4206960668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.