Evidence map›Paper›PMID 35340559›Full record

ArticleMatter2022

Immunomodulatory Microneedle Patch for Periodontal Tissue Regeneration.

Xuexiang Zhang, Mohammad Mahdi Hasani-Sadrabadi, Jana Zarubova, Erfan Dashtimighadam, Reihaneh Haghniaz, Ali Khademhosseini, Manish J Butte, Alireza Moshaverinia, Tara Aghaloo, Song Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Matter, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 159 citations in OpenAlex.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xuexiang ZhangDepartment of Bioengineering, University of California, Los Angeles, CA 90095, United States.
Mohammad Mahdi Hasani-SadrabadiDepartment of Bioengineering, University of California, Los Angeles, CA 90095, United States.
Jana ZarubovaDepartment of Bioengineering, University of California, Los Angeles, CA 90095, United States.
Erfan DashtimighadamDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-3290 United States.
Reihaneh HaghniazDepartment of Bioengineering, University of California, Los Angeles, CA 90095, United States.
Ali KhademhosseiniDepartment of Bioengineering, University of California, Los Angeles, CA 90095, United States.
Manish J ButteDepartment of Pediatrics, Division of Immunology, Allergy, and Rheumatology, University of California Los Angeles, Los Angeles, CA 90095, United States.
Alireza MoshaveriniaWeintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, California 90095, United States.
Tara AghalooDivision of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, United States.
Song LiDepartment of Bioengineering, University of California, Los Angeles, CA 90095, United States.
University of California, Los Angeles · USUniversity of North Carolina at Chapel Hill · US

Funding

Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)U24DE026914 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAI, YANG, CHEN, YONG · 2017 to 2019
$12.0M
Therapeutic microneedles for localized treatment of periodontal tissueR56DE029157 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2019 to 2019
$286k
NIDCR NIH HHS R56 DE029157NIDCR NIH HHS U24 DE026914
6 · The paper itself

Abstract

Periodontal diseases are caused by microbial infection and the recruitment of destructive immune cells. Current therapies mainly deal with bacteria elimination, but the regeneration of periodontal tissues remains a challenge. Here we developed a modular microneedle (MN) patch that delivered both antibiotic and cytokines into the local gingival tissue to achieve immunomodulation and tissue regeneration. This MN patch included a quickly dissolvable gelatin membrane for an immediate release of tetracycline and biodegradable GelMA MNs that contained tetracycline-loaded poly(lactic-co-glycolic acid) nanoparticles and cytokine-loaded silica microparticles for a sustained release. Antibiotic release completely inhibited bacteria growth, and the release of IL-4 and TGF-β induced the repolarization of anti-inflammatory macrophages and the formation of regulatory T cells

Indexed as

anti-bacteriaanti-inflammatorybiomaterialsimmunoengineeringlocal immunomodulationMicroneedles

Identifiers

PMID35340559
PMCPMC8942382
OpenAlexW4200581905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.