Evidence map›Paper›PMID 35340433›Full record

ArticleiScience2022

Zeb1 regulation of wound-healing-induced inflammation in alkali-damaged corneas.

Wei Liang, Yingnan Zhang, Liang Zhou, Xiaoqin Lu, Margaret E Finn, Wei Wang, Hui Shao, Douglas C Dean, Lijun Zhang, Yongqing Liu

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Role of ZEB1 in angiogenesis and therapeutic potential (Review).International journal of molecular medicine · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Corneal injury repair and the potential involvement of ZEB1.Eye and vision (London, England) · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Wei LiangDepartment of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Yingnan ZhangDepartment of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Liang ZhouDepartment of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Xiaoqin LuDepartment of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Margaret E FinnDepartment of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Wei WangDepartment of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Hui ShaoDepartment of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Douglas C DeanDepartment of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Lijun ZhangDepartment of Ophthalmology, Third People's Hospital of Dalian, Dalian Medical University, Dalian 116033, China.
Yongqing LiuDepartment of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
University of Louisville · USCentral South University · CNDalian Medical University · CN

Funding

Blood outer retina barrier regulationR01EY030933 · NEI · UNIVERSITY OF LOUISVILLE · PI DOUGLAS Chase DEAN · 2020 to 2026
$4.3M
Cone Rescue in Retinitis PigmentosaR01EY026158 · NEI · UNIVERSITY OF LOUISVILLE · PI DEAN, DOUGLAS CHASE, MCCALL, MAUREEN A · 2016 to 2019
$2.4M
Molecular Determinants of Developmental DefectsP20GM103453 · NIGMS · UNIVERSITY OF LOUISVILLE · PI GREENE, ROBERT M · 2012 to 2012
$1.7M
Summer Vision Sciences Training ProgramT35EY026509 · NEI · UNIVERSITY OF LOUISVILLE · PI BRIAN P. CERESA, Maureen A McCall · 2017 to 2026
$416k
NEI NIH HHS R01 EY026158NEI NIH HHS R01 EY030933NEI NIH HHS T35 EY026509NIGMS NIH HHS P20 GM103453
6 · The paper itself

Abstract

The cornea is an avascular tissue for vision clarity. Alkali burn could cause severe traumatic damage on the cornea with inflammation and neovascularization (NV), leading to vision reduction and blindness. Mechanisms underlying corneal inflammation and NV are not as clear. We previously reported that Zeb1 is an important factor in corneal NV, and we sought to clarify whether it is also involved in regulation of corneal inflammation. We analyzed the alkali burn-induced corneal inflammation and wound healing in both Zeb1

Indexed as

Biological sciencesImmunologyOphthalmology

Identifiers

PMID35340433
PMCPMC8941209
OpenAlexW4220895394

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.