Evidence map›Paper›PMID 35340394›Full record

ArticleInnovation (Cambridge (Mass.))2022

Fluctuating temperature modifies heat-mortality association around the globe.

Yao Wu, Bo Wen, Shanshan Li, Antonio Gasparrini, Shilu Tong, Ala Overcenco, Aleš Urban, Alexandra Schneider, Alireza Entezari, Ana Maria Vicedo-Cabrera and 48 more

Abstract read
In one paragraph

Article in Innovation (Cambridge (Mass.)), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Building the model: a review of input structures in extreme temperature-health.Environmental health : a global access science source · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

58 authors.

Yao WuDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia.
Bo WenDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia.
Shanshan LiDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia.
Antonio GasparriniDepartment of Public Health, Environments, and Society, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
Shilu TongShanghai Children's Medical Centre, Shanghai Jiao Tong University, Shanghai 200025, China.
Ala OvercencoNational Agency for Public Health of the Ministry of Health, Labour, and Social Protection of the Republic of Moldova, Chisinau MD-2009, Republic of Moldova.
Aleš UrbanInstitute of Atmospheric Physics, Czech Academy of Sciences, Prague 141 00, Czech Republic.
Alexandra SchneiderInstitute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85747, Germany.
Alireza EntezariClimate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia.
Ana Maria Vicedo-CabreraDepartment of Public Health, Environments, and Society, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
Antonella ZanobettiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
Antonis AnalitisDepartment of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens 11527, Greece.
Ariana ZekaInstitute for Environment, Health, and Societies, Brunel University London, London UB8 3PN, UK.
Aurelio TobiasInstitute of Environmental Assessment and Water Research, Spanish Council for Scientific Research, Barcelona 08034, Spain.
Barrak AlahmadDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
Ben ArmstrongDepartment of Public Health, Environments, and Society, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
Bertil ForsbergDepartment of Public Health and Clinical Medicine, Umeå University, Umeå 901 87, Sweden.
Carmen ÍñiguezDepartment of Statistics and Computational Research, Universitat de València, València 46003, Spain.
Caroline AmelingNational Institute for Public Health and the Environment (RIVM), Centre for Sustainability and Environmental Health, Bilthoven 3720 BA, Netherlands.
César De la Cruz ValenciaDepartment of Environmental Health, National Institute of Public Health, Cuernavaca Morelos 62100, Mexico.
Christofer ÅströmDepartment of Public Health and Clinical Medicine, Umeå University, Umeå 901 87, Sweden.
Danny HouthuijsNational Institute for Public Health and the Environment (RIVM), Centre for Sustainability and Environmental Health, Bilthoven 3720 BA, Netherlands.
Do Van DungDepartment of Environmental Health, Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 17000, Vietnam.
Dominic RoyéCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid 28029, Spain.
Ene IndermitteInstitute of Family Medicine and Public Health, University of Tartu, Tartu 50090, Estonia.
Eric LavigneSchool of Epidemiology & Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Fatemeh MayvanehFaculty of Geography and Environmental Sciences, Hakim Sabzevari University, Sabzevar 9617976487, Iran.
Fiorella AcquaottaDepartment of Earth Sciences, University of Turin, Turin 10125, Italy.
Francesca de'DonatoDepartment of Epidemiology, Lazio Regional Health Service, Rome 00147, Italy.
Francesco SeraDepartment of Statistics, Computer Science, and Applications "G. Parenti", University of Florence, Florence 50121, Italy.
Gabriel Carrasco-EscobarHealth Innovation Laboratory, Institute of Tropical Medicine "Alexander von Humboldt", Universidad Peruana Cayetano Heredia, Lima 15102, Peru.
Haidong KanDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.
Hans OrruInstitute of Family Medicine and Public Health, University of Tartu, Tartu 50090, Estonia.
Ho KimGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
Iulian-Horia HolobacaFaculty of Geography, Babeş-Bolyai University, Cluj-Napoca 400084, Romania.
Jan KyselýInstitute of Atmospheric Physics, Czech Academy of Sciences, Prague 141 00, Czech Republic.
Joana MadureiraEPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto 4050-600, Portugal.
Joel SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
Klea KatsouyanniDepartment of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens 11527, Greece.
Magali Hurtado-DiazDepartment of Environmental Health, National Institute of Public Health, Cuernavaca Morelos 62100, Mexico.
Martina S RagettliSwiss Tropical and Public Health Institute, Basel 4051, Switzerland.
Masahiro HashizumeDepartment of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, Japan.
Mathilde PascalSanté Publique France, Department of Environmental Health, French National Public Health Agency, Saint Maurice 94 410, France.
Micheline de Sousa Zanotti Stagliorio CoélhoDepartment of Pathology, Faculty of Medicine, University of São Paulo, São Paulo 05508-270, Brazil.
Noah ScovronickGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Paola MichelozziDepartment of Epidemiology, Lazio Regional Health Service, Rome 00147, Italy.
Patrick GoodmanTechnological University Dublin, Dublin D07 EWV4, Ireland.
Paulo Hilario Nascimento SaldivaINSPER, São Paulo 04546-042, Brazil.
Rosana AbrutzkyUniversidad de Buenos Aires, Facultad de Ciencias Sociales, Instituto de Investigaciones Gino Germani, Buenos Aires C1053ABH, Argentina.
Samuel OsorioDepartment of Environmental Health, University of São Paulo, São Paulo 01246-904, Brazil.
Tran Ngoc DangDepartment of Environmental Health, Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 17000, Vietnam.
Valentina ColistroDepartment of Quantitative Methods, School of Medicine, University of the Republic, Montevideo 11200, Uruguay.
Veronika HuberIBE-Chair of Epidemiology, Ludwig Maximilian University Munich, Munich 81377, Germany.
Whanhee LeeSchool of the Environment, Yale University, New Haven, CT 06511, USA.
Xerxes SeposoSchool of Tropical Medicine and Global Health, Nagasaki University, Nagasaki 852-8521, Japan.
Yasushi HondaCenter for Climate Change Adaptation, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan.
Michelle L BellSchool of the Environment, Yale University, New Haven, CT 06511, USA.
Yuming GuoDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia.

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
Medical Research Council MR/R013349/1NIEHS NIH HHS P30 ES019776
6 · The paper itself

Abstract

Studies have investigated the effects of heat and temperature variability (TV) on mortality. However, few assessed whether TV modifies the heat-mortality association. Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries. TV was calculated as the standard deviation of the average of the same and previous days' minimum and maximum temperatures. We used location-specific quasi-Poisson regression models with an interaction term between the cross-basis term for mean temperature and quartiles of TV to obtain heat-mortality associations under each quartile of TV, and then pooled estimates at the country, regional, and global levels. Results show the increased risk in heat-related mortality with increments in TV, accounting for 0.70% (95% confidence interval [CI]: -0.33 to 1.69), 1.34% (95% CI: -0.14 to 2.73), 1.99% (95% CI: 0.29-3.57), and 2.73% (95% CI: 0.76-4.50) of total deaths for Q1-Q4 (first quartile-fourth quartile) of TV. The modification effects of TV varied geographically. Central Europe had the highest attributable fractions (AFs), corresponding to 7.68% (95% CI: 5.25-9.89) of total deaths for Q4 of TV, while the lowest AFs were observed in North America, with the values for Q4 of 1.74% (95% CI: -0.09 to 3.39). TV had a significant modification effect on the heat-mortality association, causing a higher heat-related mortality burden with increments of TV. Implementing targeted strategies against heat exposure and fluctuant temperatures simultaneously would benefit public health.

Indexed as

heatmodification effectmortalitytemperature variability

Identifiers

PMID35340394
PMCPMC8942841

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.