Evidence map›Paper›PMID 35339885›Full record

ArticleJournal of pharmaceutical and biomedical analysis2022

Pharmaceutical analysis by NMR can accommodate strict impurity thresholds: The case of choline.

Prabhakar S Achanta, Matthias Niemitz, J Brent Friesen, Fatkhulla K Tadjimukhamedov, Anton Bzhelyansky, Gabriel I Giancaspro, Shao-Nong Chen, Guido F Pauli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical and biomedical analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. QuantitativeMolecules (Basel, Switzerland) · 2026
    Review
  2. Review
  3. Choline-An Essential Nutrient with Health Benefits and a Signaling Molecule.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Quantum-Mechanical DrivenACS omega · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Prabhakar S AchantaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Pharmacognosy Institute, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA.
Matthias NiemitzNMR Solutions Limited, Tulliportinkatu 3 A 8, 70100 Kuopio, Finland.
J Brent FriesenPharmacognosy Institute, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Center for Natural Product Technologies (CENAPT), College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Physical Sciences Department, Rosary College of Arts and Sciences, Dominican University, 7900 West Division Street, River Forest, IL 60305, USA.
Fatkhulla K TadjimukhamedovThe United States Pharmacopeial Convention, 12601 Twinbrook Pkwy, Rockville, MD 20852, USA.
Anton BzhelyanskyThe United States Pharmacopeial Convention, 12601 Twinbrook Pkwy, Rockville, MD 20852, USA.
Gabriel I GiancasproThe United States Pharmacopeial Convention, 12601 Twinbrook Pkwy, Rockville, MD 20852, USA.
Shao-Nong ChenDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Pharmacognosy Institute, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Center for Natural Product Technologies (CENAPT), College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA.
Guido F PauliDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Pharmacognosy Institute, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Center for Natural Product Technologies (CENAPT), College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: gfp@uic.edu.

Funding

Center for Natural Product Technologies at UIC (CeNAPT)U41AT008706 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PAULI, GUIDO F · 2015 to 2019
$1.5M
NCCIH NIH HHS U41 AT008706
6 · The paper itself

Abstract

The ICH guidelines recommend reporting thresholds for regular impurities in drug substances at the level of 0.05% or 0.03% (w/w) depending on the maximum daily intake. Therefore, any instrumental method of analysis applicable to the impurity analysis should be able to detect and quantify the analytes at those levels. This investigation was designed to verify the suitability of

Indexed as

CholineDrug ContaminationChromatography, High Pressure LiquidMagnetic Resonance ImagingMagnetic Resonance SpectroscopyPharmaceutical PreparationsCholinePharmaceutical Preparations(1)H NMR spectroscopyBenchtop NMRCholine chlorideLimit of Detection

Identifiers

PMID35339885
PMCPMC9038706

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.