Evidence map›Paper›PMID 35339812›Full record

ArticlePsychoneuroendocrinology2022

Psychological resilience and diurnal salivary cortisol in young adulthood.

Kristen Nishimi, Karestan C Koenen, Brent A Coull, Suzanne C Segerstrom, S Bryn Austin, Laura D Kubzansky

Open access · greenAbstract read
In one paragraph

Article in Psychoneuroendocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kristen NishimiMental Health Service, San Francisco Veterans Affairs Healthcare System, San Francisco, CA 94121, USA; Department of Psychiatry and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address: Kristen.nishimi@ucsf.edu.
Karestan C KoenenDepartment of Epidemiology, Harvard TH Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA; Department of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Brent A CoullDepartment of Biostatistics, Harvard TH Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Suzanne C SegerstromDepartment of Psychology, University of Kentucky, 106-B Kastle Hall, Lexington, KY 40506, USA.
S Bryn AustinDepartment of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Laura D KubzanskyDepartment of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Harvard University · USSan Francisco VA Health Care System · USUniversity of Kentucky · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Training Program in Psychiatric Genetics and Translational ResearchT32MH017119 · NIMH · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KARESTAN C KOENEN, Jukka-Pekka Onnela · 1985 to 2026
$8.9M
Sexual Orientation and Obesity: Test of a Gendered Biopsychosocial ModelR01HD066963 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI AUSTIN, S BRYN · 2011 to 2015
$3.5M
Causes and Impact of Minority Stress on Health and Development in YouthR01HD057368 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI AUSTIN, S BRYN, ROSARIO, MARGARET · 2009 to 2013
$3.3M
NICHD NIH HHS R01 HD057368NICHD NIH HHS R01 HD066963NIEHS NIH HHS P30 ES000002NIMH NIH HHS T32 MH017119
6 · The paper itself

Abstract

backgroundAdversity exposure and the negative psychological responses that often result have been linked with poor physical health outcomes and deteriorative physiological processes, like dysregulated circulating cortisol. Individuals exposed to early adversity who also demonstrate positive psychological functioning may be characterized as psychologically resilient, but few studies have evaluated whether psychological resilience may disrupt the health-damaging effects of adversity. We tested the hypothesis that among young adults exposed to early adversity, those who are psychologically resilient may manifest more normative diurnal cortisol patterns relative to those who experience more psychological distress.

methodsData are from Growing Up Today Study I participants who provided information on psychological resilience and diurnal salivary cortisol (n = 916). Psychological resilience was derived from self-report questionnaires administered between 2007 and 2010, and salivary cortisol was obtained from saliva samples collected between 2011 and 2014. The predictor of interest, psychological resilience, was defined using two domains: (1) adversity exposure measured via a count of 7 potential psychosocial adversities experienced before age 18, and (2) psychological health in young adulthood measured via a composite score reflecting low psychological distress and high positive affect. The outcome was mean log-transformed diurnal salivary cortisol across 4 samples from one day. Linear regressions evaluated associations of adversity, psychological health, and their potential multiplicative interaction with mean diurnal log-transformed cortisol, adjusting for baseline socio-demographic variables and biological and behavioral factors from the day of saliva sampling.

resultsRelatively few individuals with high adversity demonstrated positive psychological health. Both adversity exposure and psychological health were independently associated with mean log cortisol levels. Models stratified by lower versus higher adversity suggested complex relationships with cortisol, however the interaction between adversity and psychological health was not statistically significant. High adversity was associated with blunted cortisol levels, regardless of psychological health. Conversely, among those with lower adversity, overall levels of cortisol were higher and psychological health associated with more normative, lower cortisol levels.

conclusionsPsychological resilience domains were independently associated with diurnal salivary cortisol in young adulthood. High burden of early adversity may disrupt the physiological stress system, while psychological health may be associated with more normative cortisol levels when adversity is low.

Indexed as

HydrocortisoneResilience, PsychologicalAdolescentAdultCircadian RhythmHumansHypothalamo-Hypophyseal SystemMental HealthSalivaStress, PsychologicalYoung AdultHydrocortisoneDiurnal cortisolEarly adversityPsychological healthPsychological resilience

Identifiers

PMID35339812
PMCPMC9081221
OpenAlexW4221020728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.