Evidence map›Paper›PMID 35339672›Full record

SynthesisClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2022

COVID-19-Associated cardiac pathology at the postmortem evaluation: a collaborative systematic review.

Raghed Almamlouk, Tarek Kashour, Sawsan Obeidat, Melanie C Bois, Joseph J Maleszewski, Osama A Omrani, Rana Tleyjeh, Elie Berbari, Zaher Chakhachiro, Bassel Zein-Sabatto and 43 more

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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  8. Sex differences in the cardiac stress response following SARS-CoV-2 infection of ferrets.American journal of physiology. Heart and circulatory physiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

53 authors at 20 institutions in 12 countries.

Raghed AlmamloukCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Tarek KashourDepartment of Cardiac Sciences, King Fahad Cardiac Center, King Saud University Medical City, Riyadh, Saudi Arabia.
Sawsan ObeidatCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Melanie C BoisDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Joseph J MaleszewskiDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Osama A OmraniThe Royal London Hospital, Barts Health NHS Trust, London, UK; Barts and the London School of Medicine and Dentistry, Queen Mary University, London, UK.
Rana TleyjehCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Elie BerbariDivision of Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Zaher ChakhachiroDepartment of Pathology and Laboratory Medicine, American University of Beirut, Beirut, Lebanon.
Bassel Zein-SabattoDepartment of Pathology and Laboratory Medicine, American University of Beirut, Beirut, Lebanon.
Dana GerberiMayo Clinic Libraries, Mayo Clinic, Rochester, MN, USA.
Imad M TleyjehCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Division of Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Infectious Diseases Section, Department of Medical Specialties King Fahad Medical City, Riyadh, Saudi Arabia; Division of Epidemiology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. Electronic address: Tleyjeh.Imad@mayo.edu.
Cardiac Autopsy in COVID-19 Study Group
Alberto E Paniz MondolfiDepartment of Pathology, Molecular and Cell-Based Medicine, New York, NY, USA.
Aloke V FinnCVPath Institute, Inc., Gaithersburg, and University of Maryland, Baltimore, MD, USA.
Amaro Nunes Duarte-NetoDepartamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Amy V RapkiewiczNYU Winthrop Hospital, Department of Pathology, Long Island School of Medicine, Long Island, NY, USA.
Andrea FrustaciDepartment of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, La Sapienza University, Rome, Italy; Cellular and Molecular Cardiology Lab, IRCCS L. Spallanzani, Rome, Italy.
Arthur-Atilla KeresztesiFogolyan Kristof Emergency County Hospital, Covasna County Institution of Forensic Medicine, Covasna, Romania.
Brian HanleyDepartment of Cellular Pathology, Northwest London Pathology, Imperial College London NHS Trust, London, UK; Centre for Inflammatory Disease, Imperial College London, London, UK.
Bruno MärklInstitute of Pathology and Molecular Diagnostics, University Medical Center Augsburg, Augsburg, Germany.
Christelle LardiUniversity Center of Legal Medicine, Geneva University Hospital, Geneva, Switzerland.
Clare BryceIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Diana LindnerDepartment of Cardiology, University Heart and Vascular Centre, Hamburg, Germany; DZHK-German Center for Cardiovascular Research, Partner site, Hamburg/Kiel/Lübeck, Germany.
Diego AguiarUniversity Center of Legal Medicine, Geneva University Hospital, Geneva, Switzerland.
Dirk WestermannDepartment of Cardiology, University Heart and Vascular Centre, Hamburg, Germany; DZHK-German Center for Cardiovascular Research, Partner site, Hamburg/Kiel/Lübeck, Germany.
Edana StrobergOffice of the Chief Medical Examiner, Oklahoma City, OK, USA.
Eric J DuvalOffice of the Chief Medical Examiner, Oklahoma City, OK, USA.
Esther YoudForensic Medicine and Science, University of Glasgow, Glasgow, UK.
Gaetano Pietro BulfamanteUnità di Anatomia Patologica, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy; Struttura Complessa di Anatomia Patologica e Genetica Medica, ASST Santi Paolo e Carlo, Milan, Italy.
Isabelle SalmonDepartment of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium; Centre Universitaire inter Régional d'expertise en Anatomie Pathologique Hospitalière, Jumet, Belgium; DIAPath, Center for Microscopy and Molecular Imaging, ULB, Gosselies, Belgium.
Johann AuerDepartment of Cardiology and Intensive Care, St. Josef Hospital Braunau, Austria; Department of Cardiology and Intensive Care, Kepler University of Medicine Linz, Austria.
Joseph J MaleszewskiDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Klaus HirschbühlDepartment of Hematology and Clinical Oncology, University Medical Center Augsburg, Augsburg, Germany.
Lara AbsilDepartment of Pathology, Erasme Hospital, ULB, Brussels, Belgium.
Lisa M BartonOffice of the Chief Medical Examiner, Oklahoma City, OK, USA.
Luiz Fernando Ferraz da SilvaDepartamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Serviço de Verificação de Óbitos da Capital, Universidade de São Paulo, São Paulo, Brazil.
Luiza MooreDepartment of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Marisa DolhnikoffDepartamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Martin LammensDepartment of Pathology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
Melanie C BoisDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Michael OsbornDepartment of Cellular Pathology, Northwest London Pathology, Imperial College London NHS Trust, London, UK; Death Investigation Committee, Royal College of Pathologists, London, UK; Nightingale NHS Hospital, London, UK.
Myriam RemmelinkDepartment of Pathology, Erasme Hospital, ULB, Brussels, Belgium.
Paulo Hilario Nascimento SaldivaDepartamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Philippe G JorensInfla-Med Research Consortium of Excellence, University of Antwerp, Antwerp, Belgium; Department of Medicine and Health Sciences, Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium; Department of Intensive Care Medicine, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
Randall CraverChildren's Hospital of New Orleans and Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Renata Aparecida de Almeida MonteiroDepartamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Roberto ScendoniInstitute of Legal Medicine, Department of Law, University of Macerata, Macerata, Italy.
Sanjay MukhopadhyayDepartment of Pathology, Cleveland Clinic, Cleveland, OH, USA.
Tadaki SuzukiNational Institute of Infectious Diseases, Tokyo, Japan.
Thais MauadDepartamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Tony FracassoUniversity Center of Legal Medicine, Geneva University Hospital, Geneva, Switzerland.
Zachary GrimesIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Universidade de São Paulo · BRAlfaisal University · SAMayo Clinic in Arizona · USOffice of Chief Medical Examiner · USUniversity Centre of Legal Medicine · CHAmerican University of Beirut · LBAntwerp University Hospital · BEErasmus Hospital · BEGerman Centre for Cardiovascular Research · DEIcahn School of Medicine at Mount Sinai · USImperial College London · GBMayo Clinic · USArad County Clinical Hospital · ROAzienda Socio Sanitaria Territoriale Santi Paolo e CarloCambridge University Hospitals NHS Foundation Trust · GBCentre Hospitalier Universitaire de Liège · BEChildren's Hospital of New Orleans · USCleveland Clinic · USCVPath Institute · USKepler Universitätsklinikum · AT

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundMany postmortem studies address the cardiovascular effects of COVID-19 and provide valuable information, but are limited by their small sample size.

objectivesThe aim of this systematic review is to better understand the various aspects of the cardiovascular complications of COVID-19 by pooling data from a large number of autopsy studies. DATA SOURCES: We searched the online databases Ovid EBM Reviews, Ovid Embase, Ovid Medline, Scopus, and Web of Science for concepts of autopsy or histopathology combined with COVID-19, published between database inception and February 2021. We also searched for unpublished manuscripts using the medRxiv services operated by Cold Spring Harbor Laboratory. STUDY ELIGIBILITY CRITERIA: Articles were considered eligible for inclusion if they reported human postmortem cardiovascular findings among individuals with a confirmed SARS coronavirus type 2 (CoV-2) infection.

participantsConfirmed COVID-19 patients with post-mortem cardiovascular findings.

interventionsNone.

methodsStudies were individually assessed for risk of selection, detection, and reporting biases. The median prevalence of different autopsy findings with associated interquartile ranges (IQRs).

resultsThis review cohort contained 50 studies including 548 hearts. The median age of the deceased was 69 years. The most prevalent acute cardiovascular findings were myocardial necrosis (median: 100.0%; IQR, 20%-100%; number of studies = 9; number of patients = 64) and myocardial oedema (median: 55.5%; IQR, 19.5%-92.5%; number of studies = 4; number of patients = 46). The median reported prevalence of extensive, focal active, and multifocal myocarditis were all 0.0%. The most prevalent chronic changes were myocyte hypertrophy (median: 69.0%; IQR, 46.8%-92.1%) and fibrosis (median: 35.0%; IQR, 35.0%-90.5%). SARS-CoV-2 was detected in the myocardium with median prevalence of 60.8% (IQR 40.4-95.6%).

conclusionsOur systematic review confirmed the high prevalence of acute and chronic cardiac pathologies in COVID-19 and SARS-CoV-2 cardiac tropism, as well as the low prevalence of myocarditis in COVID-19.

Indexed as

COVID-19MyocarditisAgedAutopsyHumansLungSARS-CoV-2Cardiac pathologyCOVID-19MyocarditisPostmortemSARS-CoV-2Systematic review

Identifiers

PMID35339672
PMCPMC8941843
OpenAlexW4220956145

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.