ArticleJournal of theoretical biology2022
Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment.
Article in Journal of theoretical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- High frame ratebioRxiv : the preprint server for biology · 2026Article
- Stretch and flow at the gliovascular interface: High-fidelity modeling of astrocyte endfeet.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A review of cerebrospinal fluid circulation with respect to Chiari-like malformation and syringomyelia in brachycephalic dogs.Fluids and barriers of the CNS · 2025Review
- Gaps in the wall of a perivascular space act as valves to produce a directed flow of cerebrospinal fluid: a hoop-stress model.Journal of the Royal Society, Interface · 2024Article
- Spontaneous vasomotion propagates along pial arterioles in the awake mouse brain like stimulus-evoked vascular reactivity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance.Fluids and barriers of the CNS · 2023Article
- Cerebrospinal Fluid Flow.Annual review of fluid mechanics · 2023Article
- Geometry-induced rectification of looped oscillatory flows.Physical review fluids · 2023Article
- The glymphatic system: Current understanding and modeling.iScience · 2022Review
- Investigating molecular transport in the human brain from MRI with physics-informed neural networks.Scientific reports · 2022Article
- Fluid transport in the brain.Physiological reviews · 2022Review
- Brain cerebrospinal fluid flow.Physical review fluids · 2021Article
- Peristaltic pumping in thin non-axisymmetric annular tubes.Journal of fluid mechanics · 2021Article
- Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain.Scientific reports · 2021Article
- Peristaltic flow in the glymphatic system.Scientific reports · 2020Article
- The mechanisms behind perivascular fluid flow.PloS one · 2020Article
- Impact of partial slip and lateral walls on peristaltic transport of a couple stress fluid in a rectangular duct.Science progressArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Cerebrospinal fluid (CSF) flows through the perivascular spaces (PVSs) surrounding cerebral arteries. Revealing the mechanisms driving that flow could bring improved understanding of brain waste transport and insights for disorders including Alzheimer's disease and stroke. In vivo velocity measurements of CSF in surface PVSs in mice have been used to argue that flow is driven primarily by the pulsatile motion of artery walls - perivascular pumping. However, fluid dynamics theory and simulation have predicted that perivascular pumping produces flows differing from in vivo observations starkly, particularly in the phase and relative amplitude of flow oscillation. We show that coupling theoretical and simulated flows to more realistic end boundary conditions, using resistance and compliance values measured in mice instead of using periodic boundaries, results in velocities that match observations more closely in phase and relative amplitude of oscillation, while preserving the existing agreement in mean flow speed. This quantitative agreement among theory, simulation, and in vivo measurement further supports the idea that perivascular pumping is an important CSF driver in physiological conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.