Evidence map›Paper›PMID 35339489›Full record

ArticleThe Journal of biological chemistry2022

Accessibility of ENaC extracellular domain central core residues.

Lei Zhang, Xueqi Wang, Jingxin Chen, Thomas R Kleyman, Shaohu Sheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Acid-sensing ion channel 2a assembles with epithelial NaThe Journal of biological chemistry · 2026
    Article
  2. Article
  3. Epithelial Na+ Channels, Immune Cells, and Salt.Annual review of physiology · 2025
    Review
  4. Epithelial NaComprehensive Physiology · 2024
    Review
  5. The Role of Ion-Transporting Proteins in Human Disease.International journal of molecular sciences · 2024
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Lei ZhangDepartments of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xueqi WangDepartments of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jingxin ChenDepartments of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Thomas R KleymanDepartments of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: kleyman@pitt.edu.
Shaohu ShengDepartments of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
University of Pittsburgh · USCentral South University · CN

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
ENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Annet Kirabo, Thomas R Kleyman · 2019 to 2026
$4.6M
NHLBI NIH HHS R01 HL147818NIDDK NIH HHS P30 DK079307
6 · The paper itself

Abstract

The epithelial Na

Indexed as

CadmiumEpithelial Sodium ChannelsAnimalsCysteineIonsMiceProtein ConformationSodiumCadmiumCysteineEpithelial Sodium ChannelsIonsScnn1a protein, mouseSodiumacid-sensing ion channel (ASIC)allosteric regulationamiloridechannel gatingepithelial sodium channel (ENaC)extracellular domainhomology modelingNa(+) self-inhibitionprotein domaintwo-electrode voltage clamp

Identifiers

PMID35339489
PMCPMC9052164
OpenAlexW4221000936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.