Evidence map›Paper›PMID 35339181›Full record

ArticleCurrent neuropharmacology2023

Noradrenaline and Seizures: A Perspective on the Role of Adrenergic Receptors in Limbic Seizures.

Francesca Biagioni, Roberta Celli, Stefano Puglisi-Allegra, Ferdinando Nicoletti, Filippo Sean Giorgi, Francesco Fornai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current neuropharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Francesca BiagioniI.R.C.C.S. Neuromed, Pozzilli, Italy.
Roberta CelliI.R.C.C.S. Neuromed, Pozzilli, Italy.
Stefano Puglisi-AllegraI.R.C.C.S. Neuromed, Pozzilli, Italy.
Ferdinando NicolettiI.R.C.C.S. Neuromed, Pozzilli, Italy.
Filippo Sean GiorgiHuman Anatomy, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Francesco FornaiI.R.C.C.S. Neuromed, Pozzilli, Italy.
Istituto Neurologico Mediterraneo · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNoradrenergic fibers originating from the locus coeruleus densely innervate limbic structures, including the piriform cortex, which is the limbic structure with the lowest seizure threshold. Noradrenaline (NA) modulates limbic seizures while stimulating autophagy through β

objectiveIn this perspective, we analyzed a potential role for β

methodsWe developed this perspective based on current literature on the role of NA in limbic seizures and autophagy. The perspective is also grounded on preliminary data obtained by microinfusing within AT either a β

resultsβ

conclusionNA counteracts limbic seizures. This relies on various receptors in different brain areas. The anterior piriform cortex plays a key role in patients affected by limbic epilepsy. The anticonvulsant effects of NA through β

Indexed as

AnticonvulsantsNorepinephrineAnimalsBicucullineHumansRatsRats, Sprague-DawleyReceptors, AdrenergicSeizuresAnticonvulsantsBicucullineNorepinephrineReceptors, Adrenergicadrenergic receptorsArea tempestaslimbic seizuresnoradrenalinepiriform cortexβ<sub>2</sub>-adrenergic receptors

Identifiers

PMID35339181
PMCPMC10556380
OpenAlexW4220713737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.