Evidence map›Paper›PMID 35338917›Full record

ReviewRespiratory medicine and research2022

Characteristics and outcomes of COVID-19 patients with IPF: A multi-center retrospective study.

Aykut Cilli, Ismail Hanta, Fatih Uzer, Funda Coskun, Can Sevinc, Pelin Pınar Deniz, Mehmet Parlak, Ersoy Altunok, Kemal Can Tertemiz, Ahmet Ursavas

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Respiratory medicine and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aykut CilliDepartment of Respiratory Disease, Akdeniz University, Antalya, Turkey. Electronic address: acilli@akdeniz.edu.tr.
Ismail HantaDepartment of Respiratory Disease, Cukurova University, Adana, Turkey.
Fatih UzerDepartment of Respiratory Disease, Akdeniz University, Antalya, Turkey.
Funda CoskunDepartment of Respiratory Disease, Uludag University, Bursa, Turkey.
Can SevincDepartment of Respiratory Disease, Dokuz Eylul University, Izmır, Turkey.
Pelin Pınar DenizDepartment of Respiratory Disease, Cukurova University, Adana, Turkey.
Mehmet ParlakDepartment of Respiratory Disease, Akdeniz University, Antalya, Turkey.
Ersoy AltunokDepartment of Respiratory Disease, Cukurova University, Adana, Turkey.
Kemal Can TertemizDepartment of Respiratory Disease, Dokuz Eylul University, Izmır, Turkey.
Ahmet UrsavasDepartment of Respiratory Disease, Uludag University, Bursa, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are few data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (COVID-19) infection in patients with idiopathic pulmonary fibrosis (IPF). The objective of this study is to describe the characteristics and outcomes of IPF patients confirmed COVID-19 infection.

methodsIn this retrospective, multi-center, cohort study, patients from 4 hospital medical records with known IPF and a COVID-19 diagnosis were identified. Demographic and clinical outcome data were abstracted through a review of electronic medical records.

resultsRecords for 46 patients with IPF and COVID-19 were abstracted. The mean age was 65±10 years. The most common symptom was dyspnea, followed by fever and cough. Ground-glass opacities (n = 35, 83.3%) and consolidations (n = 11, 26.1%) were the main imaging features of the disease in thorax computed tomography (CT). Twenty-four patients (52.1%) required hospitalization. Among the hospitalized patients, 16 (66.6%) were admitted to the intensive care unit (ICU), and 10 (41.6%) underwent invasive mechanical ventilation. Thirteen patients (28.2%) died of COVID-19 complications. Mortality rate was significantly associated with lower DLCO/VA, long term oxygen therapy and consolidation finding on CT of thorax (p<0.05). On multivariable analysis, neither factor was associated with hospitalization or mortality.

conclusionsIPF patients represent a vulnerable population for COVID-19, according to the high rate of hospitalization, ICU requirement, and mortality rate. Measures to minimize the risk of COVID-19 infection remain key to protect IPF patients.

Indexed as

COVID-19Idiopathic Pulmonary FibrosisAgedCohort StudiesCOVID-19 TestingHumansMiddle AgedMulticenter Studies as TopicRetrospective StudiesSARS-CoV-2Idiopathic pulmonary fibrosisInterstitial lung diseaseOutbreakPandemicSARS-CoV-2

Identifiers

PMID35338917
PMCPMC8890788

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.