ArticleDrug and alcohol dependence2022
Parental and own substance use disorder: The intersection of gender and early adversity.
Article in Drug and alcohol dependence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Family Communication Patterns and Emotional Schemas as Predictors of Addiction Tendency in Adolescents: The Mediating Role of Alexithymia.International journal of school health · 2026Article
- Socioenvironmental and mental health determinants of alcohol use among Black sexually minoritized men and transgender women: Findings from the N2 cohort study.Journal of gay & lesbian mental health · 2025Article
- Scoping review of biological and psychosocial pathways that lead from childhood adversity to early-onset substance use.Frontiers in psychiatry · 2025Review
- No change in substance use disorders or overdose after implementation of state Earned Income Tax Credit (EITC).Drug and alcohol dependence · 2024Article
- Mentalization in young patients undergoing opioid agonist treatment: Implications for clinical management.Addictive behaviors reports · 2023Article
- Age, β-endorphin, and sex dependent effects of maternal separation on locomotor activity, anxiety-like behavior, and alcohol reward.Frontiers in behavioral neuroscience · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChildren who are exposed to parental substance use disorder (SUD) have a higher risk of SUD themselves. This study examines the extent to which the association between parental and own SUD is conditional upon childhood trauma, socioeconomic status, and gender.
methodsThis study uses data from the Nashville Stress and Health Study with 1234 respondents ages 25-65 collected from 2011 to 2014, weighted be representative of the general population. The association between parental SUD and own SUD was estimated using Cox Proportional Hazard Models, controlling for covariates, and testing for interactions.
resultsOther things being equal, the risk of own SUD is more strongly associated with parental SUD in households with childhood traumas among men, but not women. Childhood trauma is not associated with own SUD in the absence of parental SUD among men. For men with parental SUD exposure, just one traumatic event is associated with a 38% increased risk of own SUD (HR=1.382, SE=.201, p < 0.05). For men, living with grandparents is associated with added SUD risk (HR=1.476, SE=.228, p < 0.05). For women, childhood trauma is not associated with own SUD, but parental SUD (HR=1.556, SE=.238, p < 0.01), and early onset mood or anxiety disorder (HR=1.682, SE=.316, p < 0.01) are. For both genders, those who are African American have lower risk of SUD than those who are White (HR=0.774, SE=.109, p < 0.05 for women; HR=0.672, SE=.079, p < 0.01 for men).
conclusionsParental SUD is associated with a substantial increase in risk for own SUD, and this association differs by gender and early trauma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.