ArticleHormones and behavior2022
The onset of puberty in colony-housed male and female titi monkeys (Plecturocebus cupreus): Possible effects of oxytocin treatment during peri-adolescent development.
Article in Hormones and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Inferring fine-scale rates of mutation and recombination in the coppery titi monkey (Plecturocebus cupreus).Heredity · 2026Article
- Inferring the Demographic History of Coppery Titi Monkeys (Plecturocebus cupreus) From High-Quality, Whole-Genome, Population-Level Data.American journal of primatology · 2026Article
- Characterization of de novo germline mutations suggests a strong male mutation bias in coppery titi monkeys (Plecturocebus cupreus).Molecular biology and evolution · 2026Article
- The expression of father-daughter bond behaviors influences adult partner attachment in titi monkeys.Scientific reports · 2025Article
- Sexual selection and pseudogenization in primate fertilization.Evolution; international journal of organic evolution · 2025Article
- How does oxytocin modulate human behavior?Molecular psychiatry · 2025Review
- Age, pair tenure and parenting, but not face identity, predict looking behaviour in a pair-bonded South American primate.Animal behaviour · 2024Article
- Oxytocin and its links through scientific lineage.Comprehensive psychoneuroendocrinology · 2024Article
- Expression of bond-related behaviors affects titi monkey responsiveness to oxytocin and vasopressin treatments.Annals of the New York Academy of Sciences · 2024Article
- Oxytocin: A developmental journey.Comprehensive psychoneuroendocrinology · 2023Review
- Titi monkey father-daughter bond-related behaviors explain stress response variability.Psychoneuroendocrinology · 2023Article
- Parental experience is linked with lower vasopressin receptor 1a binding and decreased postpartum androgens in titi monkeys.Journal of neuroendocrinology · 2023Article
- Pairing status and stimulus type predict responses to audio playbacks in female titi monkeys.Frontiers in ecology and evolution · 2023Article
- Effects of Chronic and Acute Intranasal Oxytocin Treatments on Temporary Social Separation in Adult Titi Monkeys (Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Oxytocin has been used to treat neurodevelopmental conditions in adolescent patients but possible effects on reproductive development have not been well investigated. The effects of daily intra-nasal oxytocin treatment (12-18 months of age) on puberty and fertility were studied in colony-housed, male and female titi monkeys (Plecturocebus cupreus). Body weight, urinary conjugated pregnanes and estrogens (defining cyclicity) in females, and androgens and sperm in urine of in males, were measured from 1 to 3 years of age to detect puberty. Serum testosterone was also measured in males at 13, 23 and 33 months of age and hemi-castration at 3 years of age enabled assessment of testicular morphometry and oxytocin receptor expression. An oxytocin treatment*time interaction suggested a minor, transient suppression in weight gain after treatment ended. Note that females weighed 10% less across all ages. Oxytocin-treated females exhibited early, spurious ovulations but neither regular cyclicity (≈30 months) nor pregnancies were affected by treatment. Oxytocin did not affect the pubertal increase in urinary androgen or the first appearance of sperm, which occurred as early as 15 months of age. Treatment did delay the puberty-associated rise in serum testosterone in males. All males were pubertal by 22 months and all females by 32 months of age. Although no major male or female fertility outcome was observed, oxytocin demonstrated some physiological effects through a delay of testosterone secretion in males, induction of precocious ovulation in females, and a suppression of general weight gain for the months following treatment.
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