Evidence map›Paper›PMID 35338445›Full record

ArticleIrish journal of medical science2023

Evaluation of the accuracy of multiplex polymerase chain reaction in differentiation between bacterial and viral meningitis.

Mahmoud Abdelfattah Ahmed, Gamal A Askar, Hekma S Farghaly, Asmaa O Ahmed, Dalia T Kamal, Shorook S Ahmed, Ismail L Mohamad

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Irish journal of medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03387969 (Role of CSF-CRPand Serum Procalcitonin in Differentiation Between Bacterial and Viral Meningitis in Children), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03387969 unknown statusnot on this map

Role of CSF-CRPand Serum Procalcitonin in Differentiation Between Bacterial and Viral Meningitis in Children

TypeobservationalSponsorAssiut UniversityRan2018 to 2020Enrolled80ConditionsMeningitis in ChildrenArmsCSF sample
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mahmoud Abdelfattah AhmedPediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt.
Gamal A AskarPediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt.
Hekma S FarghalyPediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt.
Asmaa O AhmedClinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt.
Dalia T KamalClinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt.
Shorook S AhmedMedical Student, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt.
Ismail L MohamadPediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt. ismail231@aun.edu.eg.ORCID http://orcid.org/0000-0001-8252-9220
Assiut University · EG

Funding

Faculty of Medicine, Assiut University 2018-01-04-006-R2
6 · The paper itself

Abstract

backgroundMeningitis is one of the most dangerous infection affecting children. The need for rapid and accurate diagnosis is mandatory for improving the outcome. AIM OF THE WORK: To evaluate the role of multiplex polymerase chain reaction (PCR) in diagnosis of meningitis either bacterial or viral and to detect its accuracy. PATIENTS AND

methodsA cross-sectional study was carried out in University Children Hospital, Faculty of Medicine, between November 2019 and September 2020. The study was approved by the Ethics Review Board of Faculty of Medicine, Assiut University, and informed written consent was obtained. The committee's reference number is 17200161. Clinicaltrails.gov ID: NCT03387969. Forty-eight children aged 2 to 18 years with meningitis were included. Detailed history and examination, blood glucose level at time of admission prior to lumbar puncture, and multiplex PCR in cerebrospinal fluid (CSF) were evaluated.

resultsThe mean age of children was 3.27 ± 1.27 years. Thirty-five (72.9%) cases were bacterial meningitis while 13 (27.1%) cases were viral meningitis. Multiplex PCR had 94% sensitivity and 100% specificity for diagnosis of bacterial meningitis.

conclusionMultiplex PCR may help in diagnosis and differentiation of bacterial and viral meningitis with accurate and rapid results.

Indexed as

Meningitis, BacterialMeningitis, ViralBacteriaChildChild, PreschoolCross-Sectional StudiesHumansMultiplex Polymerase Chain ReactionSensitivity and SpecificityCerebrospinal fluidChildrenMeningitisMultiplex PCR

Identifiers

PMID35338445
PMCPMC9892078
OpenAlexW4221100087

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.