Evidence map›Paper›PMID 35338434›Full record

ArticleTranslational stroke research2022

Fronto-Parietal and White Matter Haemodynamics Predict Cognitive Outcome in Children with Moyamoya Independent of Stroke.

Eun Jung Choi, Robyn Westmacott, Fenella J Kirkham, Amanda Robertson, Prakash Muthusami, Manohar Shroff, Mahendranath Moharir, Tricia Williams, Peter Dirks, Daune MacGregor and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Translational stroke research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Eun Jung ChoiNeurosciences and Mental Health Program, Stroke Imaging Laboratory for Children, The Hospital for Sick Children, Toronto, ON, Canada.
Robyn WestmacottDepartment of Neuropsychology, The Hospital for Sick Children, Toronto, ON, Canada.
Fenella J KirkhamDevelopmental Neurosciences and Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health, London, UK.
Amanda RobertsonNeurosciences and Mental Health Program, Stroke Imaging Laboratory for Children, The Hospital for Sick Children, Toronto, ON, Canada.
Prakash MuthusamiDiagnostic Imaging, The Hospital for Sick Children, ON, Toronto, Canada.
Manohar ShroffDiagnostic Imaging, The Hospital for Sick Children, ON, Toronto, Canada.
Mahendranath MoharirStroke Program, Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Tricia WilliamsDepartment of Neuropsychology, The Hospital for Sick Children, Toronto, ON, Canada.
Peter DirksDepartment of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.
Daune MacGregorStroke Program, Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Mahmoud SlimChild Health Evaluative Sciences Program, The Hospital for Sick Children, Toronto, ON, Canada.
Elizabeth PulcineStroke Program, Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Ishvinder BhathalStroke Program, Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Matsanga Leyila KasekaStroke Program, Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Andrea KassnerMedical Imaging, University of Toronto, ON, Toronto, Canada.
William LoganStroke Program, Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Gabrielle deVeberStroke Program, Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Nomazulu DlaminiNeurosciences and Mental Health Program, Stroke Imaging Laboratory for Children, The Hospital for Sick Children, Toronto, ON, Canada. nomazulu.dlamini@sickkids.ca.ORCID http://orcid.org/0000-0001-5927-3132
Hospital for Sick Children · CAUniversity of Toronto · CAUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Moyamoya disease is a major arteriopathy characterised by progressive steno-occlusion of the arteries of the circle of Willis. Studies in adults with moyamoya suggest an association between abnormal fronto-parietal and white matter regional haemodynamics and cognitive impairments, even in the absence of focal infarction. However, these associations have not been investigated in children with moyamoya. We examined the relationship between regional haemodynamics and ratings of intellectual ability and executive function, using hypercapnic challenge blood oxygen level-dependent magnetic resonance imaging of cerebrovascular reactivity in a consecutive cohort of children with confirmed moyamoya. Thirty children were included in the final analysis (mean age: 12.55 ± 3.03 years, 17 females, 15 idiopathic moyamoya and 15 syndromic moyamoya). Frontal haemodynamics were abnormal in all regardless of stroke history and comorbidity, but occipital lobe haemodynamics were also abnormal in children with syndromic moyamoya. Executive function deficits were noted in both idiopathic and syndromic moyamoya, whereas intellectual ability was impaired in syndromic moyamoya, even in the absence of stroke. Analysis of the relative effect of regional abnormal haemodynamics on cognitive outcomes demonstrated that executive dysfunction was predominantly explained by right parietal and white matter haemodynamics independent of stroke and comorbidity, while posterior circulation haemodynamics predicted intellectual ability. These results suggest that parietal and posterior haemodynamics play a compensatory role in overcoming frontal vulnerability and cognitive impairment.

Indexed as

Moyamoya DiseaseStrokeWhite MatterAdolescentAdultChildCognitionFemaleHemodynamicsHumansMagnetic Resonance ImagingBOLD MRI CVRCerebrovascular reactivityExecutive functionMoyamoyaStroke

Identifiers

PMID35338434
OpenAlexW4221110348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.