ArticleJournal of assisted reproduction and genetics2022
Fine-tuning IVF laboratory key performance indicators of the Vienna consensus according to female age.
Article in Journal of assisted reproduction and genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Cleavage stage versus blastocyst stage transfers in patients with a single zygote: an emulated target trial.Human reproduction (Oxford, England) · 2026Article
- Correlation analysis of a novel artificial intelligence optical microscope-assisted semen assessment system with IVF outcomes.Journal of assisted reproduction and genetics · 2025Article
- Effect of maternal age, embryo number and quality on pregnancy outcome during frozen embryo transfer cycle.Frontiers in endocrinology · 2025Article
- Adjusting key performance indicators in ART laboratories according to controlled ovarian stimulation protocol.Frontiers in physiology · 2025Article
- Advanced KPI framework for IVF pregnancy prediction models in IVF protocols.Scientific reports · 2024Article
- Clinical and laboratory key performance indicators in IVF: A consensus between the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR) and the Italian Society of Embryology, Reproduction and Research (SIERR).Journal of assisted reproduction and genetics · 2023Article
- Quality assurance (QA) for monitoring the performance of assisted reproductive technology (ART) staff using artificial intelligence (AI).Journal of assisted reproduction and genetics · 2023Article
- Positive and Negative Aspects of Public Insurance Coverage on ART With Respect to Multiple Gestation in Japan.Reproductive medicine and biologyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo test the validity of the Vienna consensus laboratory key performance indicators (KPIs) to monitor the outcome of treatments involving women of different age ranges.
methodsThe retrospective cohort study included 862 complete IVF/ICSI cycles carried out between January 2014 and May 2021. All embryos of each cycle cohort were subject to extended culture. The overall population was divided into two groups according to female age: the Vienna consensus (≤ 39 years) and older female age (≥ 40 years). We compared outcomes of a selection of the Vienna performance indicators (PIs) and KPIs, with a focus on measures relevant to embryo cleavage and blastocyst formation. A possible association between total good blastocyst development rate (TGBDR) and cumulative clinical pregnancy rate (CPR) was also assessed.
resultsNo differences were observed in fertilization and embryo cleavage KPIs between the Vienna consensus and the older female age group (standard IVF fertilization, 67.2 vs. 67.3; ICSI fertilization, 72.3 vs. 75.3; day 2 development, 57.6% vs 58.7%; day 3 development, 52.4% vs. 50.7%, respectively). TGBDR was lower in the older female age group (45.5% vs. 33.4% p < 0.001). Multivariate logistic regression analysis indicated female age as a factor independently associated with TGBDR. Clinical outcomes significantly decreased with increasing female age.
conclusionThe study suggests that, while most laboratory outcome measures are reliably applicable irrespective of female age, KPIs describing extended embryo culture should be fine-tuned in consideration of older female age.
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