ArticleJournal of assisted reproduction and genetics2022
The impact of preimplantation genetic testing for aneuploidies (PGT-A) on clinical outcomes in high risk patients.
Article in Journal of assisted reproduction and genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Short Communication: Conflicting Conclusions in PGT-A: Live Birth Rates per Initiated Cycle or Oocyte Retrieval Show No Benefit, but Significant Improvement per Embryo Transfer.JBRA assisted reproduction · 2026Pooled it
- Does preimplantation genetic testing for aneuploidy improve live birth rate in women diagnosed with recurrent implantation failure: A systematic review and meta-analysis?Acta obstetricia et gynecologica Scandinavica · 2026Pooled it
- Preimplantation genetic testing for aneuploidy optimizes reproductive outcomes in recurrent reproductive failure: a systematic review.Frontiers in medicine · 2024Pooled it
- Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential.Frontiers in endocrinology · 2024Pooled it
- A systematic review and meta-analysis: clinical outcomes of recurrent pregnancy failure resulting from preimplantation genetic testing for aneuploidy.Frontiers in endocrinology · 2023Pooled it
- Human biomarker navigator.iMeta · 2026Review
- Review
- Elevated maternal pre-transfer serum lipid peroxidation is associated with implantation failure and early pregnancy loss.BMC medicine · 2026Article
- PGT-A versus expectant management for fertile patients with recurrent pregnancy loss and prior aneuploidy: a dual-center, real-world study of 5-year cumulative pregnancy outcomes.Frontiers in endocrinology · 2026Observational
- Mapping the evidence and research gaps on preimplantation genetic testing for aneuploidy in recurrent implantation failure: a scoping review.Frontiers in endocrinology · 2026Article
- Preimplantation genetic testing for aneuploidy in young women with recurrent spontaneous abortion.Medicine · 2025Observational
- How Many Blastocysts Are Needed for PGT-A to Benefit RPL Patients? A 7-Year Retrospective Cohort Study.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Changes in sequencing technology used for preimplantation genetic testing for aneuploidy.Journal of assisted reproduction and genetics · 2025Review
- Effectiveness of preimplantation genetic testing for aneuploidy in improving clinical and neonatal outcomes for patients with recurrent pregnancy loss.Frontiers in endocrinology · 2025Article
- Preimplantation genetic testing for aneuploidy in patients of different age: a systematic review and meta-analysis.Obstetrics & gynecology science · 2024Article
- Preimplantation Genetic Testing for Aneuploidy Could Not Improve Cumulative Live Birth Rate Among 705 Couples with Unexplained Recurrent Implantation Failure.The application of clinical genetics · 2024Article
- Evaluation of pre-implantation genetic testing for aneuploidy outcomes in patients without infertility undergoing in vitro fertilization compared to infertile controls.Journal of assisted reproduction and genetics · 2023Article
- Comparison of 1-year cumulative live birth and perinatal outcomes following single blastocyst transfer with or without preimplantation genetic testing for aneuploidy: a propensity score-matched study.Journal of assisted reproduction and genetics · 2023Article
- Preimplantation genetic testing for aneuploidy helps to achieve a live birth with fewer transfer cycles for the blastocyst FET patients with unexplained recurrent implantation failure.Archives of gynecology and obstetrics · 2023Article
- Is it necessary for young patients with recurrent implantation failure to undergo preimplantation genetic testing for aneuploidy?Frontiers in endocrinology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate whether preimplantation genetic testing for aneuploidy (PGT-A) improves the clinical outcome in patients with advanced maternal age (AMA), recurrent miscarriages (RM), and recurrent implantation failure (RIF).
methodsRetrospective cohort study from a single IVF center and a single genetics laboratory. One hundred seventy-six patients undergoing PGT-A were assigned to three groups: an AMA group, an RM group, and a RIF group. Two hundred seventy-nine patients that did not undergo PGT-A were used as controls and subgrouped similarly to the PGT-A cohort. For the PGT-A groups, trophectoderm biopsy was performed and array comparative genomic hybridization was used for PGT-A. Clinical outcomes were compared with the control groups.
resultsIn the RM group, we observed a significant decrease of early pregnancy loss rates in the PGT-A group (18.1% vs 75%) and a significant increase in live birth rate per transfer (50% vs 12.5%) and live birth rate per patient (36% vs 12.5%). In the RIF group, a statistically significant increase in the implantation rate per transfer (69.5% vs 33.3%) as well as the live birth rate per embryo transfer (47.8% vs 19%) was observed. In the AMA group, a statistically significant reduction in biochemical pregnancy loss was observed (3.7% vs 31.5%); however, live birth rates per embryo transfer and per patient were not significantly higher than the control group.
conclusionOur results agree with recently published studies, which suggest caution in the universal application of PGT-A in women with infertility. Instead, a more personalized approach by choosing the right candidates for PGT-A intervention should be followed.
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Registered trials
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