Trial reportJournal of perinatology : official journal of the California Perinatal Association2022
Postnatal maximal weight loss, fluid administration, and outcomes in extremely preterm newborns.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01378273 (Preterm Erythropoietin Neuroprotection Trial), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preterm Erythropoietin Neuroprotection Trial (PENUT Trial)
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Early Postnatal Weight Loss and Its Association with Outcomes in Very Preterm Neonates: A Systematic Review and Meta-Analysis.Neonatology · 2025Pooled it
- Total Fluid Administration and Weight Loss during the First 2 Weeks in Infants Randomized to Early Enteral Feeding after Extremely Preterm Birth.Neonatology · 2023Trial
- Association of Fluid Balance With Short- and Long-term Respiratory Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2022Trial
- Early fluid status and severe intraventricular hemorrhage or death in extremely preterm infants.Pediatric nephrology (Berlin, Germany) · 2026Article
- Weight changes and variability in the first week of life: associations with mortality in extremely preterm newborns.Pediatric nephrology (Berlin, Germany) · 2026Article
- Association between weight changes the first postnatal week and bronchopulmonary dysplasia-free survival in infants born at 23-26 weeks of gestation.European journal of pediatrics · 2026Observational
- Tissue Doppler Imaging, Pulmonary Haemodynamics and Conventional Echocardiographic Indices for Early Bronchopulmonary Dysplasia Prediction in Preterm Infants: A Prospective Observational Feasibility Study.Children (Basel, Switzerland) · 2026Article
- Early feeding and fluid volume associations with adverse in-hospital outcomes among premature newborns.Pediatric research · 2026Article
- [Association between early fluid overload and critical complications in extremely low birth weight infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Gregory Valentine: ECI biocommentary.Pediatric research · 2026Article
- Observational
- Lung ultrasound score and left ventricular eccentricity index in preterm infants with respiratory failure - a pilot study.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Insensible water loss in extremely preterm infants cared for in incubators with 70% and 90% relative humidity.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Evaluation of First-Week Fluid Intake and Maximal Weight Loss Percentage with In-Hospital Adverse Outcomes Among Moderately and Very Preterm Newborns in Ethiopia.Children (Basel, Switzerland) · 2025Article
- Is fluid balance in the first 14 days of life associated with respiratory outcomes in extremely premature neonates? EBM Lesson: Covariate selection in an observation study.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Predictors of bronchopulmonary dysplasia occurrence and severity in extremely preterm infants.Frontiers in pediatrics · 2025Article
- Advancements in research on fluid overload in preterm infants-a narrative review.Frontiers in pediatrics · 2025Review
- Postnatal weight loss and neurodevelopmental outcomes at age 3 years in extremely preterm infants: a cohort study.BMC pediatrics · 2024Article
- Association of different doses of antenatal corticosteroids exposure with early major outcomes and early weight loss percentage in extremely preterm infants or extremely low birthweight infants: a multicentre cohort study.BMJ paediatrics open · 2024Article
- Expected and Desirable Preterm and Small Infant Growth Patterns.Advances in nutrition (Bethesda, Md.) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveEvaluate maximal weight loss (MWL) and total fluid administration (TFA) association in first week after birth with outcomes among extremely preterm (EP) newborns. STUDY
designWe performed a retrospective analysis of the Preterm Erythropoietin Neuroprotection Trial evaluating first-week MWL, TFA, and association with in-hospital outcomes.
resultsAmong n = 883 included EP neonates, n = 842 survived ≥ 7 days and were included in outcome analyses. MWL between 5% to 15% was associated with decreased odds of necrotizing enterocolitis compared to MWL > 15% (OR 0.49, 95% CI 0.25-0.98). Average TFA > 150 mL/kg birthweight/day was associated with increased odds of necrotizing enterocolitis (OR 3.22, 95% CI 1.40-7.42) and patent ductus arteriosus requiring surgery (OR 2.14, 95% CI 1.10-4.15).
conclusionMWL between 5% to 15% is a potentially optimal window of MWL. Increasing average TFA in the first week is associated with adverse neonatal outcomes. Prospective studies evaluating MWL and TFA and relationship to outcomes in EP neonates are needed. CLINICAL
trial registrationThis study is a secondary analysis of pre-existing data from the PENUT Trial Registration: NCT01378273, https://clinicaltrials.gov/ct2/show/NCT01378273 .
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.