ArticleScientific reports2022
Zero retinal vein pulsation amplitude extrapolated model in non-invasive intracranial pressure estimation.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Quantifying Lateral Pulsation in Retinal Vessels Within the Optic Disc.Translational vision science & technology · 2026Article
- Evidence for the Existence of Two Opposing Pulse Waves in Retinal Vein Segments Within the Optic Disc.Investigative ophthalmology & visual science · 2025Article
- Calculation of vessel pulse wave velocities in retinal vein segments within the optic disc centre.Scientific reports · 2024Article
- Assessment of retinal vein pulsation through video-ophthalmoscopy and simultaneous biosignals acquisition.Biomedical optics express · 2023Article
- Empirical retinal venous pulse wave velocity using modified photoplethysmography.BMC research notes · 2023Article
- Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change.NPJ microgravity · 2023Article
- Non-Invasive Intracranial Pressure Monitoring.Journal of clinical medicine · 2023Review
- Vessel Pulse Amplitude Mapping in Eyes With Central and Hemi Retinal Venous Occlusion.Translational vision science & technology · 2023Article
- A Review of the Methods of Non-Invasive Assessment of Intracranial Pressure through Ocular Measurement.Bioengineering (Basel, Switzerland) · 2022Review
- A machine learning approach in the non-invasive prediction of intracranial pressure using Modified Photoplethysmography.PloS one · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracranial pressure (ICP) includes the brain, optic nerve, and spinal cord pressures; it influences blood flow to those structures. Pathological elevation in ICP results in structural damage through various mechanisms, which adversely affects outcomes in traumatic brain injury and stroke. Currently, invasive procedures which tap directly into the cerebrospinal fluid are required to measure this pressure. Recent fluidic engineering modelling analogous to the ocular vascular flow suggests that retinal venous pulse amplitudes are predictably influenced by downstream pressures, suggesting that ICP could be estimated by analysing this pulse signal. We used this modelling theory and our photoplethysmographic (PPG) retinal venous pulse amplitude measurement system to measure amplitudes in 30 subjects undergoing invasive ICP measurements by lumbar puncture (LP) or external ventricular drain (EVD). We estimated ICP from these amplitudes using this modelling and found it to be accurate with a mean absolute error of 3.0 mmHg and a slope of 1.00 (r = 0.91). Ninety-four percent of differences between the PPG and invasive method were between - 5.5 and + 4.0 mmHg, which compares favourably to comparisons between LP and EVD. This type of modelling may be useful for understanding retinal vessel pulsatile fluid dynamics and may provide a method for non-invasive ICP measurement.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.