ArticleScientific reports2022
A computational framework for canonical holistic morphometric analysis of trabecular bone.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 11 citations in OpenAlex.
- The impact of footwear on human talar trabecular architecture.Journal of anatomy · 2026Article
- Whole-Epiphysis Trabecular Bone in Tamarin Limbs Suggests Effects of Leaping Distance Alongside Non-Biomechanical Factors.American journal of biological anthropology · 2026Article
- SwartkransProceedings of the National Academy of Sciences of the United States of America · 2026Article
- CSGM: A R Package to Conduct a Robust Cross-Sectional Geometric Morphometric Analysis.American journal of biological anthropology · 2026Article
- Trabecular Architecture of the Proximal Tibia in Extant Hominids.American journal of biological anthropology · 2025Article
- Biomimetic structural design in 3D-printed scaffolds for bone tissue engineering.Materials today. Bio · 2025Review
- Trabecular architecture of the distal femur in extant hominids.Journal of anatomy · 2024Article
- Identification of functionally related adaptations in the trabecular network of the proximal femur and tibia of a bipedally trained Japanese macaque.Anthropological science : journal of the Anthropological Society of Nippon = Jinruigaku zasshi · 2024Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone is a remarkable, living tissue that functionally adapts to external loading. Therefore, bone shape and internal structure carry information relevant to many disciplines, including medicine, forensic science, and anthropology. However, morphometric comparisons of homologous regions across different individuals or groups are still challenging. In this study, two methods were combined to quantify such differences: (1) Holistic morphometric analysis (HMA) was used to quantify morphometric values in each bone, (2) which could then be mapped to a volumetric mesh of a canonical bone created by a statistical free-form deformation model (SDM). Required parameters for this canonical holistic morphometric analysis (cHMA) method were identified and the robustness of the method was evaluated. The robustness studies showed that the SDM converged after one to two iterations, had only a marginal bias towards the chosen starting image, and could handle large shape differences seen in bones of different species. Case studies were performed on metacarpal bones and proximal femora of different primate species to confirm prior study results. The differences between species could be visualised and statistically analysed in both case studies. cHMA provides a framework for performing quantitative comparisons of different morphometric quantities across individuals or groups. These comparisons facilitate investigation of the relationship between spatial morphometric variations and function or pathology, or both.
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